A Randomized Feeding Trial of Iron-Biofortified Beans on School Children in Mexico

Iron deficiency is a major public health problem worldwide, with the highest burden among children. The objective of this randomized efficacy feeding trial was to determine the effects of consuming iron-biofortified beans (Fe-Beans) on the iron status in children, compared to control beans (Control-...

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Bibliographic Details
Published in:Nutrients 2019-02, Vol.11 (2), p.381
Main Authors: Finkelstein, Julia L, Mehta, Saurabh, Villalpando, Salvador, Mundo-Rosas, Veronica, Luna, Sarah V, Rahn, Maike, Shamah-Levy, Teresa, Beebe, Stephen E, Haas, Jere D
Format: Article
Language:English
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Abbreviations
Anemia
Beans
Bioavailability
biofortification
Boarding schools
Body mass
Body mass index
Body size
C-reactive protein
Children
Children & youth
Clinical trials
Crop diseases
Endocytosis
Feeding
Ferritin
Global health
Hemoglobin
Inflammation
Infrastructure
international nutrition
Iron
Malnutrition
Mexico
Normality
Nutrition
Population studies
Proteins
Public health
Randomization
Rural areas
Transferrin
Transferrins
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Summary:Iron deficiency is a major public health problem worldwide, with the highest burden among children. The objective of this randomized efficacy feeding trial was to determine the effects of consuming iron-biofortified beans (Fe-Beans) on the iron status in children, compared to control beans (Control-Beans). A cluster-randomized trial of biofortified beans ( ), bred to enhance iron content, was conducted over 6 months. The participants were school-aged children ( = 574; 5⁻12 years), attending 20 rural public boarding schools in the Mexican state of Oaxaca. Double-blind randomization was conducted at the school level; 20 schools were randomized to receive either Fe-Beans ( = 10 schools, = 304 students) or Control-Beans ( = 10 schools, = 366 students). School administrators, children, and research and laboratory staff were blinded to the intervention group. Iron status (hemoglobin (Hb), serum ferritin (SF), soluble transferrin receptor (sTfR), total body iron (TBI), inflammatory biomarkers C-reactive protein (CRP) and -1-acid glycoprotein (AGP)), and anthropometric indices for individuals were evaluated at the enrollment and at the end of the trial. The hemoglobin concentrations were adjusted for altitude, and anemia was defined in accordance with age-specific World Health Organization (WHO) criteria (i.e., Hb
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11020381