The Role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signaling in the Hippocampal Dentate Gyrus

Pituitary adenylate cyclase-activating polypeptide (PACAP, ) dysregulation has been associated with multiple stress-related psychopathologies that may be related to altered hippocampal function. In coherence, PACAP- and PAC1 receptor ( )-null mice demonstrate changes in hippocampal-dependent behavio...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2020-04, Vol.14, p.111-111
Main Authors: Johnson, Gregory C, Parsons, Rodney, May, Victor, Hammack, Sayamwong E
Format: Article
Language:English
Subjects:
Amino acids
Behavior
Cellular Neuroscience
Circuits
contextual fear conditioning
Dentate gyrus
Granule cells
Hippocampus
PAC1 protein
PAC1 receptor
Pain
Pituitary adenylate cyclase-activating polypeptide
Polypeptides
Post traumatic stress disorder
Roles
Structure-function relationships
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Summary:Pituitary adenylate cyclase-activating polypeptide (PACAP, ) dysregulation has been associated with multiple stress-related psychopathologies that may be related to altered hippocampal function. In coherence, PACAP- and PAC1 receptor ( )-null mice demonstrate changes in hippocampal-dependent behavioral responses, implicating the PACAPergic system function in this structure. Within the hippocampus, the dentate gyrus (DG) may play an important role in discerning the differences between similar contexts, and DG granule cells appear to both highly express PAC1 receptors and receive inputs from PACAP-expressing terminals. Here, we review the evidence from our laboratories and others that PACAP is an important regulator of activity within hippocampal circuits, particularly within the DG. These data are consistent with an increasing literature implicating PACAP circuits in stress-related pathologies such as post-traumatic stress disorder (PTSD) and implicate the hippocampus, and in particular the DG, as a critical site in which PACAP dysregulation can alter stress-related behaviors.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2020.00111