Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis

While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of d...

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Bibliographic Details
Published in:PloS one 2019-03, Vol.14 (3), p.e0212796
Main Authors: Morimoto, Juliano, Senior, Alistair, Ruiz, Kate, Wali, Jibran A, Pulpitel, Tamara, Solon-Biet, Samantha M, Cogger, Victoria C, Raubenheimer, David, Le Couteur, David G, Simpson, Stephen J, Eberhard, Joerg
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - diagnostic imaging
Alveolar Bone Loss - etiology
Alveolar Bone Loss - pathology
Alveolar Process - diagnostic imaging
Alveolar Process - pathology
Animals
Biology and Life Sciences
Dietary Proteins - administration & dosage
Dietary Proteins - adverse effects
Dietary Sucrose - administration & dosage
Dietary Sucrose - adverse effects
Disease Models, Animal
Feeding Behavior
Health aspects
Humans
Male
Medicine and Health Sciences
Methylene blue
Mice
Mice, Inbred C57BL
Nutrition
Organ Size
Periodontitis
Periodontitis - etiology
Physical Sciences
Research and Analysis Methods
Starch
Starch - administration & dosage
Starch - adverse effects
Sucrose
Sugar
Type 2 diabetes
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Summary:While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0212796