Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis

Dim light at night (dLAN) has become a pervasive part of the modern world, and growing evidence shows its association with increased health risks. Though this link is attributed to a disturbed circadian clock, the underlying mechanisms that can explain how circadian disruption from dLAN causes negat...

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Bibliographic Details
Published in:Frontiers in immunology 2021-01, Vol.11, p.614960-614960
Main Authors: Okuliarova, Monika, Mazgutova, Nikoleta, Majzunova, Miroslava, Rumanova, Valentina Sophia, Zeman, Michal
Format: Article
Language:English
Subjects:
chemokines
chronodisruption
Immunology
leukocyte trafficking
monocytes
renal redox balance
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Summary:Dim light at night (dLAN) has become a pervasive part of the modern world, and growing evidence shows its association with increased health risks. Though this link is attributed to a disturbed circadian clock, the underlying mechanisms that can explain how circadian disruption from dLAN causes negative health effects remain unclear. Here, we exposed rats to a light-dark cycle (12:12 h) with low-intensity light at night (~2 lx) for 2 and 5 weeks and explored the steady-state pattern of circulating immune cells and renal immune-related markers, which are well controlled by the circadian clock. After 5 weeks, dLAN impaired the daily variation in several types of white blood cells, especially monocytes and T cells. Two-week dLAN caused a reduction in blood monocytes and altered gene expression of macrophage marker and monocyte-attracting chemokine in the kidney. Interestingly, dLAN decreased renal 3-nitrotyrosine levels and resulted in up-regulation of the main endogenous antioxidant pathways, indicating a disturbance in the renal redox balance and an activation of compensatory mechanisms. These effects paralleled the altered renal expression of the molecular clock components and increased plasma corticosterone levels. Together, our results show that chronic exposure to dLAN weakened the circadian control of daily variation of circulating immune cells and disturbed renal immune and redox homeostasis. Consequences of this dLAN-disturbed immune balance on the ability of the immune system to cope with other challenges should by clarified in further studies.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.614960