Influence of short‐term training on functional capacity and (anti‐)inflammatory immune signalling in acute hospitalization

• Published in: Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2020-08, Vol.11 (4), p.1154-1157
• Main Authors: Ramírez‐Vélez, Robinson, Martínez‐Velilla, Nicolás, Fernández‐Irigoyen, Joaquín, Santamaría, Enrique, Palomino‐Echeverría, Sara, Izquierdo, Mikel
• Format: Article
• Language: English
• Subjects: Chemokines; Cytokines; Fitness training programs; Gait; Hospitalization; Intervention; Letter to the Editor; Ligands; Older people; Patients; Proteins
• ISSN: 2190-5991; 2190-6009
• DOI: 10.1002/jcsm.12582

Introduction It has been shown that 7 days of in‐hospital inactivity induces a rapid decline (>10%) in total lean leg mass in healthy older adults, 1 and loss of muscle mass has been associated with a lower likelihood of survival after hospitalization in older patients. 2 In this regard, chronic, low‐grade inflammation is a hallmark of aging and is associated with changes in body composition and declining physical function, making older adults even more vulnerable to the negative impact of hospitalization. 2 The release of muscle‐derived myokines is responsible for many of the beneficial effects of exercise in older adults, particularly by promoting a healthy anti‐inflammatory milieu 3 and may thus complement the anti‐inflammatory and analgesic actions of medications. Furthermore, a significant negative correlation was observed between ΔSCF levels and 1RM chest press (r = −0.399, P = 0.028) and Δhandgrip strength/body weight (r = −0.343 P = 0.047) from baseline to exercise. 1 TABLEResults of endpoints by group Variable Exercise group Control group Between‐group difference (95% CI) P‐value SPPB (balance, gait ability, leg strength), score a 1.35 (2.23 to 0.46) 0.33 (−1.33 to 0.66) 1.02 (−0.20 to 2.24) 0.098 Handgrip strength, kg 1.51 (2.91 to 0.10) −0.99 (−0.33 to 2.32) 2.50 (0.73 to 4.28) 0.007 Handgrip strength, kg/body weight, kg 0.01 (−0.00 to 0.03) −0.02 (−0.04 to 3.08) 0.04 (0.01 to 0.06) 0.013 Gait speed, m/s −0.11 (−0.18 to −0.04) 0.01 (−0.10 to 0.09) −0.10 (−0.21 to 0.00) 0.061 1RM chest press, kg 3.63 (6.99 to 0.27) −1.91 (−0.78 to 4.61) 5.55 (1.70 to 9.40) 0.006 1RM chest press, kg/body weight, kg 0.02 (0.01 to 0.06) 0.05 (0.10 to 0.01) 0.08 (0.03 to 0.14)