Short Physical Performance Battery and Incident Cardiovascular Events Among Older Women

Background The Short Physical Performance Battery (SPPB) is an inexpensive, reliable, and easy-to-implement measure of lower-extremity physical function. Strong evidence links SPPB scores with all-cause mortality, but little is known about its relationship with incident cardiovascular disease (CVD)....

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-07, Vol.9 (14), p.e016845
Main Authors: Bellettiere, John, Lamonte, Michael J, Unkart, Jonathan, Liles, Sandy, Laddu-Patel, Deepika, Manson, JoAnn E, Banack, Hailey, Seguin-Fowler, Rebecca, Chavez, Paul, Tinker, Lesley F, Wallace, Robert B, LaCroix, Andrea Z
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
balance
Cardiovascular Diseases - epidemiology
Cohort Studies
Exercise Test - statistics & numerical data
Female
frailty
gait speed
geriatric cardiology
healthy cardiovascular aging
Humans
Incidence
Original Research
physical functioning
United States - epidemiology
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Summary:Background The Short Physical Performance Battery (SPPB) is an inexpensive, reliable, and easy-to-implement measure of lower-extremity physical function. Strong evidence links SPPB scores with all-cause mortality, but little is known about its relationship with incident cardiovascular disease (CVD). Methods and Results Women (n=5043, mean age=79±7) with no history of myocardial infarction or stroke completed 3 timed assessments-standing balance, strength (5 chair stands), and usual gait speed (4 m walk)-yielding an SPPB score from 0 (worst) to 12 (best). Women were followed for CVD events (myocardial infarction, stroke, or CVD death) up to 6 years. Hazard ratios were estimated for women with (0-3), (4-6), (7-9), and (10-12) SPPB scores using Cox proportional hazard models adjusted for demographic, behavioral, and health-related variables including objective measurements of physical activity, blood pressure, lipids, and glucose levels. Restricted cubic splines tested linearity of associations. With 361 CVD cases, crude incidence rates/1000 person-years were 41.0, 24.3, 16.1, and 8.6 for , , and SPPB categories, respectively. Corresponding fully adjusted hazard ratios (95% CIs) were 2.28 (1.50-3.48), 1.70 (1.23-2.36) 1.49 (1.12-1.98), and 1.00 (referent); -trend
ISSN:2047-9980
2047-9980
DOI:10.1161/jaha.120.016845