Comparative prognostic value of different preoperative complete blood count cell ratios in patients with oral cavity cancer treated with surgery and postoperative radiotherapy

Background We sought to compare the prognostic significance of different preoperative complete blood count cell ratios in patients with oral cavity squamous cell carcinoma (OSCC) treated with surgery and postoperative radiotherapy (PORT). Methods We retrospectively reviewed the clinical records of 8...

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Published in:Cancer medicine (Malden, MA) MA), 2021-03, Vol.10 (6), p.1975-1988
Main Authors: Wu, Yao‐Yu, Chang, Kai‐Ping, Ho, Tsung‐Ying, Chou, Wen‐Chi, Hung, Sheng‐Ping, Fan, Kang‐Hsing, Chiang, Yin‐Yin, Chou, Yung‐Chih, Tsang, Ngan‐Ming
Format: Article
Language:English
Subjects:
Blood
Blood tests
Cancer therapies
Chemotherapy
Clinical Cancer Research
distant metastasis
Leukocytes (neutrophilic)
Lymphocytes
lymphocyte‐to‐monocyte ratio
Medical prognosis
Monocytes
Multivariate analysis
Neutrophils
neutrophil‐to‐lymphocyte ratio
Oral cavity
oral cavity squamous cell carcinoma
Original Research
overall survival
Patients
platelet‐to‐lymphocyte ratio
Radiation therapy
Risk factors
Smoking
Squamous cell carcinoma
Surgery
Variables
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Summary:Background We sought to compare the prognostic significance of different preoperative complete blood count cell ratios in patients with oral cavity squamous cell carcinoma (OSCC) treated with surgery and postoperative radiotherapy (PORT). Methods We retrospectively reviewed the clinical records of 890 patients with OSCC who were treated with surgery and PORT. The following preoperative complete blood count cell ratios were collected: neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR). Overall survival (OS), local control, regional control, and distant control (DC) served as the main outcomes of interest. Results The results of multivariate analysis in the entire study cohort revealed that a low NLR was the only independently favorable marker of both OS (adjusted hazard ratio [HR]: 0.794, 95% confidence interval (CI): 0.656–0.961, bootstrap p = 0.028) and DC (adjusted HR: 0.659, 95% CI: 0.478–0.909, bootstrap p = 0.015). Both LMR and PLR were not retained in the model as independent predictors. Subgroup analyses in high‐risk patients (i.e., those bearing T4 disease, N3 disease, or poor differentiation) revealed that a high NLR was a significant adverse risk factor for both OS and DC (all p 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.3738