Prognostic value of pre-treatment neutrophil-to-lymphocyte ratio in patients with brain metastasis from cancer: a meta-analysis

Evidence shows that inflammatory responses play an essential role in the development of brain metastases (BM). The goal of this meta-analysis was to critically evaluate the literature regarding the use of the neutrophil to lymphocyte ratio (NLR) to predict the prognosis of patients with BM to help c...

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Bibliographic Details
Published in:Scientific reports 2024-10, Vol.14 (1), p.24789-8, Article 24789
Main Authors: Zhou, Ke, Wan, Jun, Li, Yile, Yuan, Yi, Liu, Qian, Li, Huixuan, Jiang, Xinyi, Yuan, Xiang, Zhang, Sen, Zhang, Yu
Format: Article
Language:English
Subjects:
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Brain cancer
Brain metastasis
Brain Neoplasms - blood
Brain Neoplasms - mortality
Brain Neoplasms - secondary
Humanities and Social Sciences
Humans
Leukocytes (neutrophilic)
Lymphocyte Count
Lymphocytes
Medical prognosis
Meta-analysis
Metastases
Metastasis
multidisciplinary
Neutrophils
NLR
Prognosis
Science
Science (multidisciplinary)
Sensitivity analysis
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Summary:Evidence shows that inflammatory responses play an essential role in the development of brain metastases (BM). The goal of this meta-analysis was to critically evaluate the literature regarding the use of the neutrophil to lymphocyte ratio (NLR) to predict the prognosis of patients with BM to help clinicians institute early interventions and improve outcomes. We conducted systematic review and meta-analysis, utilizing data from prominent databases, including PubMed, Cochrane Library and China National Knowledge Infrastructure databases. Our inclusion criteria encompassed studies investigating the studies that assessed the association between NLR and overall survival (OS). We included 11 articles, with 2629 eligible patients, to evaluate the association between NLR and OS. High NLR was significantly associated with shorter OS, with a pooled hazard ratio (HR) of 1.82 (95% CI 1.57–2.11). Subgroup analysis revealed that this association was consistent across different regions, with HRs of 2.03 (95% CI 1.67–2.46) in Asian populations and 1.58 (95% CI 1.35–1.84) in non-Asian populations. Additionally, in a subgroup analysis based on NLR cut-off values, patients with NLR ≥ 3 had an HR of 1.69 (95% CI 1.46–1.96), while those with NLR 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-76305-0