Filterability of Erythrocytes in Patients with COVID-19

For the first time, the influence of COVID-19 on blood microrheology was studied. For this, the method of filtering erythrocytes through filters with pores of 3.5 μm was used. Filterability was shown to significantly decrease with the increasing severity of the patient’s condition, as well as with a...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-06, Vol.12 (6), p.782
Main Authors: Prudinnik, Dmitry S., Sinauridze, Elena I., Shakhidzhanov, Soslan S., Bovt, Elizaveta A., Protsenko, Denis N., Rumyantsev, Alexander G., Ataullakhanov, Fazoil I.
Format: Article
Language:English
Subjects:
Blood
Blood vessels
C-reactive protein
Capillaries
Coronaviruses
COVID-19
Deformability
dynamics of filterability alteration
erythrocyte
Erythrocytes
filterability
Hematocrit
Hemoglobin
inflammation
Mechanical ventilation
Oxygen
Patients
Prognosis
Rheology
Severe acute respiratory syndrome coronavirus 2
Shear stress
SpO2/FiO2 ratio
Viscosity
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Summary:For the first time, the influence of COVID-19 on blood microrheology was studied. For this, the method of filtering erythrocytes through filters with pores of 3.5 μm was used. Filterability was shown to significantly decrease with the increasing severity of the patient’s condition, as well as with a decrease in the ratio of hemoglobin oxygen saturation to the oxygen fraction in the inhaled air (SpO2/FiO2). The filterability of ≤ 0.65, or its fast decrease during treatment, were indicators of a poor prognosis. Filterability increased significantly with an increase in erythrocyte count, hematocrit and blood concentrations of hemoglobin, albumin, and total protein. The effect of these parameters on the erythrocyte filterability is directly opposite to their effect on blood macrorheology, where they all increase blood viscosity, worsening the erythrocyte deformability. The erythrocyte filterability decreased with increasing oxygen supply rate, especially in patients on mechanical ventilation, apparently not due to the oxygen supplied, but to the deterioration of the patients’ condition. Filterability significantly correlates with the C-reactive protein, which indicates that inflammation affects the blood microrheology in the capillaries. Thus, the filterability of erythrocytes is a good tool for studying the severity of the patient’s condition and his prognosis in COVID-19.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12060782