Association between lymphocyte-to-monocyte ratio and stroke-associated pneumonia: a retrospective cohort study

Stroke-associated pneumonia (SAP) is a common complication of acute ischemic stroke (AIS) and is associated with increased mortality and prolonged hospital stays. The lymphocyte-to-monocyte ratio (LMR) is a novel inflammatory marker that has been shown to be associated with various diseases. However...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2024-09, Vol.12, p.e18066, Article e18066
Main Authors: Li, Xiaoqiang, Zhou, Xiangmao, Wang, Hui, Ruan, Baifu, Song, Zhibin, Zhang, Guifeng
Format: Article
Language:English
Subjects:
Acute ischemic stroke
Aged
Analysis
Bacterial pneumonia
Biomarkers - blood
China
Development and progression
Female
Health aspects
Humans
Incidence
Ischemia
Ischemic Stroke - blood
Ischemic Stroke - epidemiology
Ischemic Stroke - immunology
Leukocyte Count
Lymphocyte Count
Lymphocyte-to-monocyte ratio
Lymphocytes
Male
Medical research
Medicine, Experimental
Middle Aged
Monocytes - immunology
Mortality
Pneumonia
Pneumonia - blood
Pneumonia - diagnosis
Pneumonia - epidemiology
Pneumonia - immunology
Retrospective cohort study
Retrospective Studies
Stroke (Disease)
Stroke - blood
Stroke - epidemiology
Stroke - immunology
Stroke-associated pneumonia
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Summary:Stroke-associated pneumonia (SAP) is a common complication of acute ischemic stroke (AIS) and is associated with increased mortality and prolonged hospital stays. The lymphocyte-to-monocyte ratio (LMR) is a novel inflammatory marker that has been shown to be associated with various diseases. However, the relationship between the LMR and SAP in patients with AIS remains unclear. A retrospective cohort study was conducted on 1,063 patients with AIS admitted to our hospital within 72 hours of symptom onset. Patients were divided into two groups: the SAP group (  = 99) and the non-SAP group (  = 964). The LMR was measured within 24 hours of admission, and the primary outcome was the incidence of SAP. We used univariate and multivariate logistic regression analyses to assess the relationship between the LMR and SAP. Additionally, curve-fitting techniques and subgroup analyses were conducted. The incidence of SAP was 9.31%. We found that the LMR was significantly lower in the SAP group than in the non-SAP group (2.46 ± 1.44 3.86 ± 1.48,  
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.18066