Oxidative stress in experimental vitiligo C57BL/6 mice

To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final dest...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of dermatology 2009-07, Vol.54 (3), p.221-224
Main Authors: Jalel, Akrem, Yassine, Mrabet, Hamdaoui, Mohamed Hédi
Format: Article
Language:English
Subjects:
Antioxidant status
Antioxidants
Aqueous solutions
Basic Research
catalase
Causes of
Development and progression
glutathione peroxydase
Lipids
malondialdehyde
Mice
Oxidative stress
Pathogenesis
Physiological aspects
Risk factors
Rodents
Skin
Skin diseases
Studies
superoxide dismutase
Vitiligo
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate whether oxidative stress is implicated in melanocyte damage in vitiligo. Vitiligo is a complex disorder characterized by gradually enlarging areas of depigmentation. A new unifying hypothesis for the etiology of this pigment disorder is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, as the result of a breakdown in free radical defense. We evaluated 18 vitiligo mice and 12 controls that were age matched. Parameters of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), and plasma malondialdehyde (MDA) were measured by spectrophotometry. MDA levels in vitiligo mice were significantly higher than in controls (P < 0.001). CAT, SOD, and glutathione peroxidase (GPx) activities in mice were significantly lower than controls (P < 0.05 and P < 0.001, respectively). Our results confirmed that oxidative stress plays an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on antioxidant parameters in experimental vitiligo mice.
ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.55628