Risk factors for the development of idiopathic macular hole: a nationwide population-based cohort study

This nationwide population-based cohort study searched for demographic, comorbid, behavioral, and reproductive risk factors for idiopathic macular hole (MH) development using data provided by the Korean National Health Insurance Service. A total of 4,496,867 individuals aged 50–79 years who particip...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.21778-13, Article 21778
Main Authors: Hwang, Sungsoon, Kang, Se Woong, Kim, Sang Jin, Choi, Jaehwan, Son, Ki Young, Lim, Dong Hui, Shin, Dong Wook, Choi, DooSeok, Chang, Yoosoo, Ryu, Seungho, Cho, Juhee
Format: Article
Language:English
Subjects:
692/308/174
692/499
692/699/3161/3175
692/699/3161/3179
Body mass index
Child
Cohort analysis
Cohort Studies
Female
Humanities and Social Sciences
Humans
Male
Medical screening
multidisciplinary
Obesity
Obesity - complications
Obesity - epidemiology
Population studies
Population-based studies
Post-menopause
Retinal Perforations - surgery
Retrospective Studies
Risk Factors
Risk taking
Science
Science (multidisciplinary)
Tomography, Optical Coherence
Vitrectomy
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This nationwide population-based cohort study searched for demographic, comorbid, behavioral, and reproductive risk factors for idiopathic macular hole (MH) development using data provided by the Korean National Health Insurance Service. A total of 4,496,867 individuals aged 50–79 years who participated in the Korean National Health Screening Program in 2013 or 2014 were included. Participants were followed up until December 2018, and incident cases of idiopathic MH were identified. Prospective associations between incident idiopathic MH and various covariates were investigated using multivariable-adjusted Cox proportional hazard models. During an average follow-up period of 4.91 years, 3054 patients were newly diagnosed with idiopathic MHs. Women showed greater risk (hazard ratio of 1.71) and earlier presentation of idiopathic MH than men. Compared to the normal body mass index group, the obese group (≥ 25 kg/m 2 ) showed a significantly lower risk of idiopathic MH. Among postmenopausal women, those with two or more children showed a greater risk of idiopathic MH than those who had not been pregnant, with a hazard ratio of 1.80. In conclusion, idiopathic MH occurred earlier and greater in women. Childbirth were associated with an increased risk of MH development, and obesity was associated with a lower risk of MH.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-25791-1