Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris

• Published in: International journal of molecular sciences 2020-08, Vol.21 (16), p.5617
• Main Authors: Holmannova, Drahomira, Borsky, Pavel, Borska, Lenka, Andrys, Ctirad, Hamakova, Kvetoslava, Rehacek, Vit, Svadlakova, Tereza, Malkova, Andrea, Beranek, Martin, Palicka, Vladimir, Krejsek, Jan, Fiala, Zdenek
• Format: Article
• Language: English
• Subjects: Adult; Blood & organ donations; Blood pressure; Body Mass Index; Case-Control Studies; Cholesterol; Chronic illnesses; Clusterin; Clusterin - genetics; Comorbidity; Diabetes; Disease; elafin; Elafin - genetics; Female; Gene Expression Regulation - genetics; Glucose; Hospitals; Humans; Immune system; Inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Middle Aged; Neutrophils; Obesity; Pathogenesis; Psoriasis; Psoriasis - complications; Psoriasis - genetics; Psoriasis - metabolism; Psoriasis - pathology; Psoriasis vulgaris; Serum levels; Severity of Illness Index; Skin; Software
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21165617

Psoriasis is a pathological condition characterized by immune system dysfunction and inflammation. Patients with psoriasis are more likely to develop a wide range of disorders associated with inflammation. Serum levels of various substances and their combinations have been associated with the presence of the disease (psoriasis) and have shown the potential to reflect its activity. The aim of the present study is to contribute to the elucidation of pathophysiological links between psoriasis, its pro-inflammatory comorbidity metabolic syndrome (MetS), and the expression of clusterin and elafin, which are reflected in the pathophysiological "portfolio" of both diseases. Clinical examinations (PASI score), ELISA (clusterin, elafin), and biochemical analyses (parameters of MetS) were performed. We found that patients with psoriasis were more often afflicted by MetS, compared to the healthy controls. Clusterin and elafin levels were higher in the patients than in the controls but did not correlate to the severity of psoriasis. Our data suggest that patients with psoriasis are more susceptible to developing other systemic inflammatory diseases, such as MetS. The levels of clusterin and elafin, which are tightly linked to inflammation, were significantly increased in the patients, compared to the controls, but the presence of MetS in patients did not further increase these levels.