Phagocytosis of Gut Bacteria by Entamoeba histolytica

The protist parasite causes amoebiasis, a major public health problem in developing countries. Only a small fraction of patients infected with the parasite display invasive disease involving colon or extra intestinal tissues such as liver. exists as two distinct forms, cysts, the infective form, and...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2019-02, Vol.9, p.34-34
Main Authors: Iyer, Lakshmi Rani, Verma, Anil Kumar, Paul, Jaishree, Bhattacharya, Alok
Format: Article
Language:English
Subjects:
Bacteria - growth & development
Cellular and Infection Microbiology
Entamoeba histolytica
Entamoeba histolytica - physiology
Feces - microbiology
Feces - parasitology
Gastrointestinal Tract - microbiology
Gastrointestinal Tract - parasitology
Humans
Lactobacillus ruminus
metagenomics
Microbial Interactions
microbiota
Phagocytosis
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Summary:The protist parasite causes amoebiasis, a major public health problem in developing countries. Only a small fraction of patients infected with the parasite display invasive disease involving colon or extra intestinal tissues such as liver. exists as two distinct forms, cysts, the infective form, and trophozoites, that are responsible for disease pathology. The latter multiply in the large intestine occasionally causing disease. The large intestine in humans is populated by a number of different bacterial communities and amoebic cells grow in their midst using some as food material. Several studies have shown relationship between bacteria and growth and virulence. However, an understanding of this relationship in human gut environment is not clear. We have investigated the possibility that there may be specific interaction of amoeba with different bacteria present in the gut environment by using a metagenomic pipe line. This was done by incubating bacteria isolated from human fecal material with and then identifying the bacterial population isolated from amoebic cells using a rRNA based metagenomic approach. Our results show that the parasite prefers a few bacterial species. One of these species is which has never shown to be associated with .
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2019.00034