Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes

Data on the relations between kidney function abnormalities and stroke in type 2 diabetes are limited. We evaluated the associations of kidney function abnormalities and chronic kidney disease (CKD) stages with incident stroke in a large sample of adults with type 2 diabetes. Participants with type...

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Published in:BMC medicine 2022-03, Vol.20 (1), p.127-127, Article 127
Main Authors: Kaze, Arnaud D, Jaar, Bernard G, Fonarow, Gregg C, Echouffo-Tcheugui, Justin B
Format: Article
Language:English
Subjects:
Albuminuria
Albuminuria - complications
Albuminuria - epidemiology
Cardiovascular diseases
Care and treatment
Complications and side effects
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetic kidney disease
Diabetic Nephropathies
Diabetics
Diagnosis
Epidemiology
Female
Glomerular Filtration Rate
Health aspects
Humans
Male
Measurement
Middle Aged
Prevention
Risk factors
Stroke
Stroke (Disease)
Stroke - complications
Stroke - epidemiology
Type 2 diabetes
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Summary:Data on the relations between kidney function abnormalities and stroke in type 2 diabetes are limited. We evaluated the associations of kidney function abnormalities and chronic kidney disease (CKD) stages with incident stroke in a large sample of adults with type 2 diabetes. Participants with type 2 diabetes from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study without history of stroke at baseline were included. Urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) were assessed at baseline. CKD categories were defined according to the KDIGO (Kidney Disease: Improving Global Outcomes) guidelines. Cox proportional hazards regression models were used to compute hazard ratios (HR) and 95% confidence intervals (CI) for stroke in relation to measures of kidney function and CKD categories. A total of 9170 participants (mean age 62.8 [SD: 6.6] years, 38.2% women, 62.9% white) were included. Over a median follow-up of 4.9 years (interquartile range: 4.0-5.7), 156 participants developed a stroke (incidence rate 3.6/1000 person-years [95% CI 3.0-4.2]). After adjusting for relevant confounders, higher UACR and lower eGFR were each associated with increased risk of stroke. Compared to UACR
ISSN:1741-7015
1741-7015
DOI:10.1186/s12916-022-02317-0