Comparative Study of TPGS and Soluplus Polymeric Micelles Embedded in Poloxamer 407 In Situ Gels for Intranasal Administration

This study aims to highlight the importance of choosing the appropriate co-polymer or co-polymer mixed combinations in order to design value-added nasal dosage forms. Local therapy of upper respiratory tract-related infections, such as nasal rhinosinusitis is of paramount importance, thus advanced l...

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Bibliographic Details
Published in:Gels 2024-08, Vol.10 (8), p.521
Main Authors: Sipos, Bence, Földes, Frézia, Budai-Szűcs, Mária, Katona, Gábor, Csóka, Ildikó
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Antibacterial agents
Antibiotics
Antimicrobial agents
Bacterial infections
Binary system
Central nervous system depressants
Comparative studies
Copolymers
Dexamethasone
Drug delivery systems
Efficiency
Encapsulation
Gelation
Gels
Health aspects
in situ gel
Instrument industry
intranasal
Micelles
Patient compliance
Permeability
Photon correlation spectroscopy
Poloxamer 407
Poloxamers
Polyethylene glycol
polymeric micelle
Polymers
R&D
Research & development
Sol-gel processes
Soluplus
Sustained release
TPGS
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Summary:This study aims to highlight the importance of choosing the appropriate co-polymer or co-polymer mixed combinations in order to design value-added nasal dosage forms. Local therapy of upper respiratory tract-related infections, such as nasal rhinosinusitis is of paramount importance, thus advanced local therapeutic options are required. Dexamethasone was encapsulated into three different polymeric micelle formulations: Soluplus or TPGS-only and their mixed combinations. Dynamic light scattering measurements proved that the particles have a micelle size less than 100 nm in monodisperse distribution, with high encapsulation efficiency above 80% and an at least 7-fold water solubility increase. Tobramycin, as an antimicrobial agent, was co-formulated into the in situ gelling systems which were optimized based on gelation time and gelation temperature. The sol-gel transition takes place between 32-35 °C, which is optimally below the temperature of the nasal cavity in a quick manner below 5 min, a suitable strategic criterion against the mucociliary clearance. In vitro drug release and permeability studies confirmed a rapid kinetics in the case of the encapsulated dexamethasone accompanied with a sustained release of tobramycin, as the hydrophilic drug.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels10080521