Adult Human Glioblastomas Harbor Radial Glia-like Cells

Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner....

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Bibliographic Details
Published in:Stem cell reports 2020-02, Vol.14 (2), p.338-350
Main Authors: Wang, Rong, Sharma, Roshan, Shen, Xiaojuan, Laughney, Ashley M., Funato, Kosuke, Clark, Philip J., Shpokayte, Monika, Morgenstern, Peter, Navare, Monalisa, Xu, Yichi, Harbi, Shaghayegh, Masilionis, Ignas, Nanjangud, Gouri, Yang, Yanhong, Duran-Rehbein, Gabriel, Hemberg, Martin, Pe'er, Dana, Tabar, Viviane
Format: Article
Language:English
Subjects:
Adult
brain tumor
cancer stem cells
Cell Line, Tumor
Genome, Human
glioblastoma
Glioblastoma - pathology
Humans
inflammation
Inflammation - pathology
Mitosis
Neuroglia - pathology
radial glia
scRNASeq
Signal Transduction
Transcription, Genetic
tumor mitosis
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Summary:Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors. •Adult human glioblastomas harbor radial glia-like cells with classic mitotic behavior•Radial glia-like tumor cell clusters exist in quiescent or cycling states•Interleukin can activate dormant radial glia-like cells into the cell cycle Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.
ISSN:2213-6711
2213-6711
DOI:10.1016/j.stemcr.2020.01.007