Stress co‐opts the gut to affect epileptogenesis. Commentary on “Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome”

[...]the respective microbiota‐transplanted rats kindled in a manner that was identical to that seen in rats that were either chronically stressed or unstressed—that is, stressed microbiota transplantation mimicked the effects of stress on non‐transplanted, kindled rats. [...]does kindling itself al...

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Bibliographic Details
Published in:Epilepsia open 2019-06, Vol.4 (2), p.230-231
Main Author: Pittman, Quentin J.
Format: Article
Language:English
Subjects:
Animals
Convulsions & seizures
Epilepsy
Feces
gut‐brain axis
Inflammatory bowel disease
kindling
microbiome
Microbiota
Stress
Studies
Transplants & implants
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Summary:[...]the respective microbiota‐transplanted rats kindled in a manner that was identical to that seen in rats that were either chronically stressed or unstressed—that is, stressed microbiota transplantation mimicked the effects of stress on non‐transplanted, kindled rats. [...]does kindling itself alter the gut microbiome and is part of the development of the kindled state due to changes in gut microbiome? In summary, this article is worthy of recognition in the journal because it is ground breaking in the epilepsy field, with exciting data that will undoubtedly lead to a better understanding of the mechanistic underpinnings for co‐morbidity in epilepsy and other medical conditions.
ISSN:2470-9239
2470-9239
DOI:10.1002/epi4.12326