Clinical outcomes of MII oocytes with refractile bodies in patients undergoing ICSI and single frozen embryo transfer

Purpose This study aimed to analyze whether the presence of refractile bodies (RFs) negatively affects fertilization, embryo development, and/or implantation rates following intracytoplasmic sperm injection (ICSI). Methods This retrospective embryo cohort study involved a total of 272 patients under...

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Published in:Reproductive medicine and biology 2020-01, Vol.19 (1), p.75-81
Main Authors: Takahashi, Hiromi, Otsuki, Junko, Yamamoto, Michio, Saito, Hiroe, Hirata, Rei, Habara, Toshihiro, Hayashi, Nobuyoshi
Format: Article
Language:English
Subjects:
Age
blastocyst
Blastocysts
Cryopreservation
cytoplasmic morphology
Embryo
embryo implantation
Embryo transfer
Embryos
Fertilization
Ganirelix
ICSI
Medical research
Medicine, Experimental
Menstruation
Mineral oils
Morphology
Oocytes
Original
Patients
Pregnancy
refractile body
Sperm
Ultrasonic imaging
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Summary:Purpose This study aimed to analyze whether the presence of refractile bodies (RFs) negatively affects fertilization, embryo development, and/or implantation rates following intracytoplasmic sperm injection (ICSI). Methods This retrospective embryo cohort study involved a total of 272 patients undergoing ICSI treatment of blastocyst cryopreservation. Results In the study, no significant differences were found regarding 2PN formation rates between RF(+) (76.5%) and RF(−) oocytes (77.2%). However, the blastocyst formation rate on Day 5 in RF(+) oocytes was 45.8%, which was significantly lower than that of 52.2% in RF(−) oocytes (aOR 0.74, 95% CI 0.59‐0.93, P = .011). Implantation rates were also significantly lower in RF(+) oocytes (24.2%) as compared to RF(−) oocytes (42.2%) (aOR 0.46, 95% CI 0.26‐0.78, P = .005). Furthermore, the implantation rate of RF(+) oocytes (28.6%), when high‐quality blastocysts were transferred, was significantly lower than that of RF(−) oocytes (46.1%) (aOR 0.50, 95% CI 0.25‐0.96, P = .043). Conclusion Our results suggest that oocytes with the presence of RFs have a lower potential for blastocyst development. Even when they develop into high‐quality blastocysts, the chances of implantation are reduced. Oocytes with the presence of RFs have a lower potential to develop into blastocysts, and even when they develop into high‐quality blastocysts, the chances of implantation are reduced.
ISSN:1445-5781
1447-0578
DOI:10.1002/rmb2.12305