Association Between Dyslipidemia and Serum Level of 25-Hydroxyvitamin-D in Early Chronic Kidney Disease, Not on Dialysis: An Observational Cross-Sectional Study from the Himalayan Country

Patients with CKD have a higher prevalence of dyslipidemia and hypovitaminosis than the normal population. Recent studies in the general population have shown a potential link between 25(OH)D and dyslipidemia. However, such evidence in the early CKD population, especially in the Nepalese setting, is...

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Bibliographic Details
Published in:International journal of nephrology and renovascular disease 2020-01, Vol.13, p.211-218
Main Authors: Sah, Shiv Kumar, Adhikary, Laxman Prasad
Format: Article
Language:English
Subjects:
25(oh)d
25-Hydroxyvitamin D
Age
Albumin
Analysis
Blood pressure
Cardiovascular diseases
Cholesterol
chronic kidney disease
Chronic kidney failure
Creatinine
Cross-sectional studies
Diabetes
Dialysis
Dyslipidemia
Epidermal growth factor receptors
Hemodialysis
High density lipoprotein
Hypertension
Kidney diseases
Laboratories
Lipids
Lipoproteins
Low density lipoprotein
Low density lipoproteins
Metabolic disorders
Original Research
Population
Population studies
Public health
Regression analysis
Teaching hospitals
Variance analysis
Vitamin D
Vitamin deficiency
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Summary:Patients with CKD have a higher prevalence of dyslipidemia and hypovitaminosis than the normal population. Recent studies in the general population have shown a potential link between 25(OH)D and dyslipidemia. However, such evidence in the early CKD population, especially in the Nepalese setting, is lacking. Thus, the present study aimed at investigating the status of 25(OH)D and dyslipidemia in the early CKD patients, and further to establish an association between 25(OH)D and lipid profile. In this cross-sectional study, we analyzed 136 clinically stable non-dialyzed CKD patients. 25(OH)D and lipid profile were evaluated as a core variable, and their direction and magnitude of a relationship were evaluated. The estimated prevalence of dyslipidemia was 49.3%, and 63.2% population had a deficiency of 25(OH)D level. Compared with the patient with normal 25(OH)D level, the patient with deficient 25(OH)D level had a significantly higher level of LDL-c ( =0.04) and lower level of HDL-C ( =0.048). Serum 25(OH)D level was significantly lower in dyslipidemic patients than non-dyslipidemic patients ( =0.015). Regression analysis demonstrated a significant inverse relationship between serum 25(OH)D levels and LDL-c (β=-1.5; =
ISSN:1178-7058
1178-7058
DOI:10.2147/IJNRD.S267252