Single-nucleus chromatin landscape dataset of mouse brain development and aging

The development and aging of the brain constitute a lifelong dynamic process, marked by structural and functional changes that entail highly coordinated cellular differentiation and epigenetic regulatory mechanisms. Chromatin accessibility serves as the foundational basis for genetic activity. Howev...

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Bibliographic Details
Published in:Scientific data 2024-06, Vol.11 (1), p.616-11
Main Authors: Ma, Yuting, Guo, Sicheng, Chen, Yixi, Peng, Yushan, Su, Xi, Jiang, Hui, Lin, Xiumei, Zhang, Jianguo
Format: Article
Language:English
Subjects:
631/114/2163
631/136/2442
631/136/509
631/208/177
Aging
Aging - genetics
Animals
Brain
Brain - growth & development
Brain - metabolism
Brain mapping
Cerebellum
Chromatin
Chromatin - metabolism
Data Descriptor
Epigenesis, Genetic
Epigenetics
Hippocampus - growth & development
Hippocampus - metabolism
Humanities and Social Sciences
Mice
multidisciplinary
Olfactory bulb
Prefrontal cortex
Prefrontal Cortex - growth & development
Prefrontal Cortex - metabolism
Science
Science (multidisciplinary)
Structure-function relationships
Transcription factors
Citations: Items that this one cites
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Description
Summary:The development and aging of the brain constitute a lifelong dynamic process, marked by structural and functional changes that entail highly coordinated cellular differentiation and epigenetic regulatory mechanisms. Chromatin accessibility serves as the foundational basis for genetic activity. However, the holistic and dynamic chromatin landscape that spans various brain regions throughout development and ageing remains predominantly unexplored. In this study, we employed single-nucleus ATAC-seq to generate comprehensive chromatin accessibility maps, incorporating data from 69,178 cells obtained from four distinct brain regions – namely, the olfactory bulb (OB), cerebellum (CB), prefrontal cortex (PFC), and hippocampus (HP) – across key developmental time points at 7 P, 3 M, 12 M, and 18 M. We delineated the distribution of cell types across different age stages and brain regions, providing insight into chromatin accessible regions and key transcription factors specific to different cell types. Our data contribute to understanding the epigenetic basis of the formation of different brain regions, providing a dynamic landscape and comprehensive resource for revealing gene regulatory programs during brain development and aging.
ISSN:2052-4463
2052-4463
DOI:10.1038/s41597-024-03382-1