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Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome
ABSTRACT Objective This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women. Methods This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 ...
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| Published in: | Endocrinology, diabetes & metabolism diabetes & metabolism, 2024-05, Vol.7 (3), p.e490-n/a |
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| container_title | Endocrinology, diabetes & metabolism |
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| creator | Saei Ghare Naz, Marzieh Mousavi, Maryam Firouzi, Faezeh Momenan, Amir Abbas Azizi, Fereidoun Ramezani Tehrani, Fahimeh |
| description | ABSTRACT
Objective
This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.
Methods
This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).
Result
In the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p |
| doi_str_mv | 10.1002/edm2.490 |
| format | article |
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Objective
This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.
Methods
This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).
Result
In the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p < 0.05), high ALT (4.76 [3.07–7.36], p < 0.05) and high HSI (8.44 [1.82–39.17], p < 0.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40], p < 0.05), the third tertile of TG/HDL‐C was associated with increased odds of elevated ALT (3.35 [2.21–5.06]) and HSI (6.55 [1.17–36.46]), whereas the second tertile of TG/HDL‐C (OR = 2.65, CI 95%: 1.74–4.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.
Conclusion
The highest tertile of TyG index and the TG/HDL‐C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.</description><identifier>ISSN: 2398-9238</identifier><identifier>EISSN: 2398-9238</identifier><identifier>DOI: 10.1002/edm2.490</identifier><identifier>PMID: 38769719</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adult ; Alanine Transaminase - blood ; Aspartate Aminotransferases - blood ; Blood Glucose - metabolism ; Blood pressure ; Cholesterol ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Diabetes ; Enzymes ; Exercise ; Fatty Liver - etiology ; Fatty Liver - physiopathology ; Female ; Glucose ; Humans ; Insulin Resistance ; Iran - epidemiology ; Lipids ; Liver - metabolism ; Liver diseases ; Liver Function Tests ; Metabolic disorders ; metabolic syndrome ; Ovaries ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - physiopathology ; Triglycerides - blood ; Womens health ; Young Adult</subject><ispartof>Endocrinology, diabetes & metabolism, 2024-05, Vol.7 (3), p.e490-n/a</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5330-7f188516060d3f1a886176be647fddb33d30b09754323e5ed2c9ad0c81adfef83</cites><orcidid>0000-0002-6470-2517 ; 0000-0002-4609-065X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3060404833/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3060404833?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11561,25752,27923,27924,37011,37012,44589,46051,46475,53790,53792,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38769719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saei Ghare Naz, Marzieh</creatorcontrib><creatorcontrib>Mousavi, Maryam</creatorcontrib><creatorcontrib>Firouzi, Faezeh</creatorcontrib><creatorcontrib>Momenan, Amir Abbas</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><creatorcontrib>Ramezani Tehrani, Fahimeh</creatorcontrib><title>Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome</title><title>Endocrinology, diabetes & metabolism</title><addtitle>Endocrinol Diabetes Metab</addtitle><description>ABSTRACT
Objective
This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.
Methods
This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).
Result
In the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p < 0.05), high ALT (4.76 [3.07–7.36], p < 0.05) and high HSI (8.44 [1.82–39.17], p < 0.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40], p < 0.05), the third tertile of TG/HDL‐C was associated with increased odds of elevated ALT (3.35 [2.21–5.06]) and HSI (6.55 [1.17–36.46]), whereas the second tertile of TG/HDL‐C (OR = 2.65, CI 95%: 1.74–4.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.
Conclusion
The highest tertile of TyG index and the TG/HDL‐C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Enzymes</subject><subject>Exercise</subject><subject>Fatty Liver - etiology</subject><subject>Fatty Liver - physiopathology</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Iran - epidemiology</subject><subject>Lipids</subject><subject>Liver - metabolism</subject><subject>Liver diseases</subject><subject>Liver Function Tests</subject><subject>Metabolic disorders</subject><subject>metabolic syndrome</subject><subject>Ovaries</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Triglycerides - blood</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>2398-9238</issn><issn>2398-9238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kl1rFDEUhgdRbKkFf4EEvPFm6kkyH5krWWurCystftDLkE3ObLPMJDWZ2WX-vdndWlvBq4RznvPwkpwse03hjAKw92h6dlY08Cw7ZrwRecO4eP7ofpSdxrgGANo0TQXsZXbERV01NW2Os-0sRq-tGqx35CMOW0RH5i6OnXXkG0YbB-U0ppKxGiNRzpCF3WAgl6PT-6lrFVSPA4ZIZr13K3Lj-yS5scMtufbdpKc4WE2uNipM5PvkTEj9V9mLVnURT-_Pk-zn5cWP8y_54urz_Hy2yHXJOeR1S4UoaQUVGN5SJURF62qJVVG3xiw5NxyW0NRlwRnHEg3TjTKgBVWmxVbwk2x-8Bqv1vIu2D6lkF5ZuS_4sJIqpHgdyqJQlGoGPM0XTFEBNQeGCgQ3LS_r5PpwcN2Nyx6NRjcE1T2RPu04eytXfiMppVCVe8O7e0Pwv0aMg-xt1Nh1yqEfo-RQpo8pWU0T-vYfdO3H4NJbJaqCAgrB-V-hDj7GgO1DGgpytx1ytx0ybUdC3zxO_wD-2YUE5Adgazuc_iuSF5--sp3wN4rYw5E</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Saei Ghare Naz, Marzieh</creator><creator>Mousavi, Maryam</creator><creator>Firouzi, Faezeh</creator><creator>Momenan, Amir Abbas</creator><creator>Azizi, Fereidoun</creator><creator>Ramezani Tehrani, Fahimeh</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6470-2517</orcidid><orcidid>https://orcid.org/0000-0002-4609-065X</orcidid></search><sort><creationdate>202405</creationdate><title>Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome</title><author>Saei Ghare Naz, Marzieh ; Mousavi, Maryam ; Firouzi, Faezeh ; Momenan, Amir Abbas ; Azizi, Fereidoun ; Ramezani Tehrani, Fahimeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5330-7f188516060d3f1a886176be647fddb33d30b09754323e5ed2c9ad0c81adfef83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Blood pressure</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Enzymes</topic><topic>Exercise</topic><topic>Fatty Liver - etiology</topic><topic>Fatty Liver - physiopathology</topic><topic>Female</topic><topic>Glucose</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Iran - epidemiology</topic><topic>Lipids</topic><topic>Liver - metabolism</topic><topic>Liver diseases</topic><topic>Liver Function Tests</topic><topic>Metabolic disorders</topic><topic>metabolic syndrome</topic><topic>Ovaries</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Triglycerides - blood</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saei Ghare Naz, Marzieh</creatorcontrib><creatorcontrib>Mousavi, Maryam</creatorcontrib><creatorcontrib>Firouzi, Faezeh</creatorcontrib><creatorcontrib>Momenan, Amir Abbas</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><creatorcontrib>Ramezani Tehrani, Fahimeh</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Wiley-Blackwell Open Access Backfiles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Endocrinology, diabetes & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saei Ghare Naz, Marzieh</au><au>Mousavi, Maryam</au><au>Firouzi, Faezeh</au><au>Momenan, Amir Abbas</au><au>Azizi, Fereidoun</au><au>Ramezani Tehrani, Fahimeh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome</atitle><jtitle>Endocrinology, diabetes & metabolism</jtitle><addtitle>Endocrinol Diabetes Metab</addtitle><date>2024-05</date><risdate>2024</risdate><volume>7</volume><issue>3</issue><spage>e490</spage><epage>n/a</epage><pages>e490-n/a</pages><issn>2398-9238</issn><eissn>2398-9238</eissn><abstract>ABSTRACT
Objective
This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.
Methods
This is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).
Result
In the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p < 0.05), high ALT (4.76 [3.07–7.36], p < 0.05) and high HSI (8.44 [1.82–39.17], p < 0.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40], p < 0.05), the third tertile of TG/HDL‐C was associated with increased odds of elevated ALT (3.35 [2.21–5.06]) and HSI (6.55 [1.17–36.46]), whereas the second tertile of TG/HDL‐C (OR = 2.65, CI 95%: 1.74–4.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.
Conclusion
The highest tertile of TyG index and the TG/HDL‐C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38769719</pmid><doi>10.1002/edm2.490</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6470-2517</orcidid><orcidid>https://orcid.org/0000-0002-4609-065X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; Open Access: Wiley-Blackwell Open Access Journals; Publicly Available Content Database |
| subjects | Adult Alanine Transaminase - blood Aspartate Aminotransferases - blood Blood Glucose - metabolism Blood pressure Cholesterol Cholesterol, HDL - blood Cross-Sectional Studies Diabetes Enzymes Exercise Fatty Liver - etiology Fatty Liver - physiopathology Female Glucose Humans Insulin Resistance Iran - epidemiology Lipids Liver - metabolism Liver diseases Liver Function Tests Metabolic disorders metabolic syndrome Ovaries Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - physiopathology Triglycerides - blood Womens health Young Adult |
| title | Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome |
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