Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima

The ethnobotanical plant has been used for hundreds of years for Dai people in Yunnan Province, China. Previously, chemical investigations on this plant have revealed that pregnane glycosides were the main biological constituents. Nine new pregnane glycosides, marsdeosides A-I ( - ), were isolated f...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-03, Vol.28 (6), p.2705
Main Authors: Meng, Qian-Qian, Tong, Shun-Yao, Peng, Xing-Rong, Zhao, Yu-Qing, Li, Zheng-Hui, Chen, He-Ping, Liu, Ji-Kai
Format: Article
Language:English
Subjects:
asclepiadaceae
Cancer
Carbon
China
Glucose
Glycosides
Glycosides - chemistry
Herbal medicine
Humans
Lipopolysaccharides
Macrophages
Marsdenia
Marsdenia - chemistry
Marsdenia tenacissima (Roxb.) moon
Medicinal plants
Nitric oxide
nitric oxide production inhibition
NMR
Nuclear magnetic resonance
Plants, Medicinal - chemistry
pregnane glycosides
Pregnanes - chemistry
Spectroscopic analysis
structural elucidation
Two dimensional analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ethnobotanical plant has been used for hundreds of years for Dai people in Yunnan Province, China. Previously, chemical investigations on this plant have revealed that pregnane glycosides were the main biological constituents. Nine new pregnane glycosides, marsdeosides A-I ( - ), were isolated from cultivated dried stems of the medicinal plant in this study. The structures were analyzed by extensive spectroscopic analysis, including 1D, 2D NMR, HRESIMS, and IR spectroscopic analysis. The absolute configurations of the sugar moieties were identified by comparing the values and specific optical rotations with those of the commercially available standard samples and the data reported in the literature. Marsdeosides A ( ) featured an unusual 8,14- -pregnane skeleton. Compounds , , and showed activity against nitric oxide production in lipopolysaccharide-activated macrophage RAW264.7, with IC values of 37.5, 38.8, and 42.8 μM (L-NMMA was used as a positive control, IC 39.3 μM), respectively. This study puts the knowledge of the chemical profile of the botanical plant one step forward and, thereby, promotes the sustainable utilization of the resources of traditional folk medicinal plants.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28062705