A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

• Published in: Genomics data 2014-12, Vol.2 (C), p.357-360
• Main Authors: Ó Broin, P., Hayde, N., Bao, Y., Ye, B., Calder, R.B., de Boccardo, G., Lubetzky, M., Ajaimy, M., Pullman, J., Colovai, A., Akalin, E., Golden, A.
• Format: Article
• Language: English
• Subjects: Antibody-mediated rejection; Data in Brief; Donor-specific antibodies; Gene expression; Kidney; Transplant
• ISSN: 2213-5960; 2213-5960
• DOI: 10.1016/j.gdata.2014.10.005

Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA+/AMR−) patients were compared to both DSA-positive, AMR-positive (DSA+/AMR+) patients as well as DSA-negative (DSA−) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR− patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084