The footprint of SARS-COV-2 infection in neonatal late sepsis

Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging. In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evalu...

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Bibliographic Details
Published in:BMC pediatrics 2024-03, Vol.24 (1), p.184-184, Article 184
Main Authors: Jamali, Zahra, Mohammadpour, Najmeh, Sinaei, Reza, Jafari, Maedeh, Sabzevari, Fatemeh, Hasannejad, Mohammad
Format: Article
Language:English
Subjects:
Antibiotics
Asymptomatic
Babies
Comparative analysis
COVID-19
Development and progression
Diagnosis
Disease transmission
Diseases
Gestational age
Immunoglobulins
Infants (Newborn)
Infections
Intensive care
Laboratories
Late sepsis
Length of stay
Neonate
Newborn babies
Pandemics
Pediatrics
Risk factors
SARS-COV-2
Sepsis
Severe acute respiratory syndrome coronavirus 2
Urine
Ventilators
Viral infections
Viruses
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Summary:Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging. In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests. 145 neonates including 81 girls and 64 boys with a mean age of 12.3 ± 5.9 days and an average hospitalization stay of 23.1 ± 15.4 days were enrolled in the study. While 76.6% of them had negative bacterial culture, 63 patients (43.4%) showed evidence of SARS-COV-2 infection in RT-PCR or serology tests. None of the underlying factors including gender, age, and laboratory investigation had a significant relationship with SARS-COV-2 infection. Similarly, the outcomes of death and length of hospitalization were not different between the two groups with positive and negative SARS-COV-2 RT-PCR (P 
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-024-04665-7