Antibacterial properties of an acrylic resin containing curcumin nanoparticles: An in vitro study

Microbial accumulation is still a significant problem with removable acrylic appliances. This study aimed to assess the antimicrobial properties of a self-cured acrylic resin containing curcumin nanoparticles (CNPs). This in vitro study used 48 acrylic discs containing 0.5%, 1%, and 2% CNPs. The ant...

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Bibliographic Details
Published in:Journal of dental research, dental clinics, dental prospects dental clinics, dental prospects, 2022-01, Vol.16 (3), p.190-195
Main Authors: Khamooshi, Pegah, Pourhajibagher, Maryam, Sodagar, Ahmad, Bahador, Abbas, Ahmadi, Badreddin, Arab, Sepideh
Format: Article
Language:English
Subjects:
acrylic resin
antimicrobial
Antimicrobial activity
Antimicrobial agents
Biofilms
Curcumin
Decalcification
Dental caries
Gingivitis
Microorganisms
Nanoparticles
Oral cavity
Original
poly (methyl methacrylate)
Silicon dioxide
Silver
Streptococcus infections
Titanium dioxide
Variance analysis
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Summary:Microbial accumulation is still a significant problem with removable acrylic appliances. This study aimed to assess the antimicrobial properties of a self-cured acrylic resin containing curcumin nanoparticles (CNPs). This in vitro study used 48 acrylic discs containing 0.5%, 1%, and 2% CNPs. The antimicrobial properties of the discs against and were evaluated using disc agar diffusion (DAD), eluted component, and biofilm inhibition tests. The growth inhibition zones were measured, and the colonies were counted after 1, 3, and 7 days. DAD test showed that none of the curcumin nanoparticle concentrations caused growth inhibition zones for any microorganisms. All the concentrations were effective against all four microorganisms in the biofilm inhibition test except 0.5% for . In the eluted component test, solutions containing 2% concentration had maximum growth inhibition of all the groups at all time intervals. An increase in curcumin nanoparticle concentration from 0.5% to 1% was effective only against . Generally, CNPs in all concentrations were effective against the biofilms of all four microorganisms assessed in this study. Therefore, incorporating 2% CNPs into acrylic resin seems suitable for clinical use.
ISSN:2008-210X
2008-2118
DOI:10.34172/joddd.2022.032