The effects of resistance training on muscular strength and hypertrophy in elderly cancer patients: A systematic review and meta-analysis

• Published in: Journal of sport and health science 2022-03, Vol.11 (2), p.194-201
• Main Author: Lee, Junghoon
• Format: Article
• Language: English
• Subjects: Aged; Cancer cachexia; Humans; Hypertrophy; Middle Aged; Muscle Strength - physiology; Muscle synthesis; Muscle, Skeletal - physiology; Neoplasms - complications; Resistance Training - methods; Review; Sarcopenia; Skeletal muscle
• ISSN: 2095-2546; 2213-2961
• DOI: 10.1016/j.jshs.2021.02.002

•Resistance training improved muscle strength but did not induce significant muscle hypertrophy.•There were no reported adverse events following resistance training in elderly cancer patients.•Muscle strength can be increased by resistance training at a moderate intensity for relatively short periods.•Resistance should be gradually increased throughout training period under the direction of practitioners. One of the most life-threatening comorbidities in elderly cancer patients is cancer cachexia, which is characterized by the ongoing loss of skeletal muscular strength and mass and is also associated with aging. There is a lack of recommendations for optimal resistance training (RT) for those patients. The purpose of this study was to systematically review and quantify the effects of RT on muscular strength and hypertrophy in elderly cancer patients. Five electronic databases were searched (until January 2020) for studies that met the following criteria: (i) cancer patients aged ≥60 years; (ii) structured and supervised RT intervention for ≥6 weeks; and (iii) measured muscular strength and/or hypertrophy. Thirteen studies (717 participants, average age = 66 years) met the inclusion criteria. RT significantly increased muscular strength (mean effect size = 0.87, 95% confidence interval (95%CI): 0.43–1.32, p < 0.001) and did not significantly induce muscle hypertrophy (mean effect size = 0.09, 95%CI: –0.14 to 0.31, p = 0.45). In subgroup analyses for muscle strength, higher weekly frequency was significantly associated with larger effect size. Egger's test showed no significant publication bias for the 2 outcomes. The results suggest that RT improves muscular strength but does not significantly induce muscle hypertrophy in elderly cancer patients. [Display omitted]