Depiction of Vaginal Microbiota in Women With High-Risk Human Papillomavirus Infection

Persistent infection with the carcinogenic human papillomavirus (HPV) is a prerequisite for the progression of cervical lesions and cancer. A growing body of research has focused on the functional role of the vaginal microbiota in the persistence of HPV infection. Understanding the microbial composi...

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Bibliographic Details
Published in:Frontiers in public health 2021-01, Vol.8, p.587298
Main Authors: Wei, Zhen-Tong, Chen, Hong-Liang, Wang, Chun-Feng, Yang, Gui-Lian, Han, Shu-Mei, Zhang, Song-Ling
Format: Article
Language:English
Subjects:
16s rRNA
bacterial vaginosis
human papillomavirus
persistent infection
Public Health
vaginal microbiota
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Summary:Persistent infection with the carcinogenic human papillomavirus (HPV) is a prerequisite for the progression of cervical lesions and cancer. A growing body of research has focused on the functional role of the vaginal microbiota in the persistence of HPV infection. Understanding the microbial composition and structure in women with high-risk (hr)-HPV infection may help reveal associations between the vaginal microbiota and HPV infection, and identify potential biomarkers. Our study investigated the vaginal microbial community in women with and without hr-HPV infection, by using rRNA gene sequencing. We found that microbial perturbations occurred in the early phase of hr-HPV infection. and were decreased, while bacteria related to bacterial vaginosis (BV), such as , and were increased. Our results could offer insights into the correlations between hr-HPV and the vaginal microbiota in the early infection period, and provide indications that the predominance of some BV-associated bacteria during hr-HPV infection may increase the risk for cervical neoplasia.
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2020.587298