Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study

Background: Aortic distensibility (AD) is an important determinant of cardiovascular (CV) morbidity and mortality. There is scant data on the association between AD measured within the descending thoracic aorta and CV outcomes. Objective: We evaluated the association of AD at the descending thoracic...

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Published in:Vascular health and risk management 2022-01, Vol.18, p.653-665
Main Authors: Sood, Michael R, Abdelmoneim, Sahar S, Dontineni, Nripen, Ivanov, Alexander, Lee, Ernest, Rubin, Michael, Vittoria, Michael, Meykler, Marcella, Ramachandran, Vidhya, Sacchi, Terrence, Brener, Sorin, Klem, Igor, Heitner, John F
Format: Article
Language:English
Subjects:
Advertising executives
aortic distensibility
Blood pressure
Cardiac patients
Cardiovascular disease
cardiovascular magnetic resonance
Coronary artery bypass
Coronary vessels
descending aorta
Diabetes
Health aspects
Heart attack
Hypertension
Kidney diseases
Magnetic resonance imaging
Mortality
Original Research
Patients
Risk factors
Stroke
Task forces
Values
Variables
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Summary:Background: Aortic distensibility (AD) is an important determinant of cardiovascular (CV) morbidity and mortality. There is scant data on the association between AD measured within the descending thoracic aorta and CV outcomes. Objective: We evaluated the association of AD at the descending thoracic aorta ([AD.sub.desc]) with the primary outcome of all-cause mortality, myocardial infarction (MI), stroke or coronary revascularization in patients referred for a cardiovascular magnetic resonance (CMR) study. Methods: 928 consecutive patients [(mean age 60 [+ or -] 17; 33% with prior cardiovascular disease (CVD))] were evaluated. [AD.sub.desc] was measured at the cross-section of the descending thoracic aorta in the 4-chamber view (via steady-state free precession [SSFP] cine sequences) and was grouped into quintiles (with the 1st quintile corresponding to the least AD, i.e., the stiffest aorta). Cox proportional-hazards regression analysis were performed for the primary outcome. Results: A total of 315 patients (34%) experienced the primary outcome during a median (25% IQR, 75% IQR) follow-up of 5.0 (0.56, 9.3) years. A decreased AD was significantly associated with hypertension, diabetes, renal disease, and dyslipidemia (p median, p
ISSN:1178-2048
1176-6344
1178-2048
DOI:10.2147/VHRM.S359632