Antibiotic resistance: Evaluation of levofloxacin treatment in acute respiratory tract infections cases at the Tasikmalaya City Health Center, Indonesia

• Published in: Journal of advanced pharmaceutical technology and research 2020-07, Vol.11 (3), p.113-116
• Main Authors: Ramdhani, Danni, Azizah, Shinta, Kusuma, Sri, Sediana, Dede
• Format: Article
• Language: English
• Subjects: acute respiratory tract infections; Analysis; Antibiotic resistance; Antibiotics; Bacteria; Clinical isolates; Conflicts of interest; Drug resistance; Drug therapy; Gram-negative bacteria; Gram-positive bacteria; Health aspects; Identification; Infection; Infections; Lactose; Levofloxacin; Medical research; Microbial drug resistance; Morphology; Mortality; Motility; Original; Parenchyma; Patient compliance; Patients; Physiology; Respiratory diseases; Respiratory tract diseases; Respiratory tract infection; Sensitivity analysis; Streptococcus infections; Urban health
• ISSN: 2231-4040; 0976-2094
• DOI: 10.4103/japtr.JAPTR_17_20

Acute respiratory tract infections (ARTIs) are an acute inflammation of the upper and lower respiratory tract caused by the infection of microorganisms or bacteria, viruses, without or accompanied by inflammation of the lung parenchyma. The use of antibiotics is one way to treat respiratory diseases. This study aims to determine the level of resistance of levofloxacin antibiotics to clinical isolates from ARTIs patients at the Tasikmalaya Health Center, Indonesia. The stages of the research included rejuvenation of clinical single isolates from ARTIs patients, identification of bacteria, and antibiotic resistance testing using the paper-disc method. The results of resistance tests from 142 single clinical isolates of acute respiratory infections showed that levofloxacin antibiotics had high levels of resistance of 50.0%, 30.95% of resistance with intermediate levels, and 19.04% were still sensitive. Bacterial identification test results showed bacteria that have been resistant to levofloxacin are from the genus Haemophillus, Streptococcus, Corynebacterium, Staphylococcus, and Bordetella. Treatment of ARTIs with the antibiotic levofloxacin shows that there has been a relatively large resistance, where the results of the identification of all bacteria showed the bacteria that cause ARTIs.