Are the Costimulatory Molecule Gene Polymorphisms (CTLA-4) Associated With Infection in Organ Transplantation? A Meta-Analysis

Organ transplantation has been linked to certain gene polymorphisms. The effect of gene polymorphisms–associated organ transplantation gene on infection, on the other hand, is yet unknown. The research studying the link between the CTLA-4 rs5742909, rs733618, rs4553808, rs231775, and polymorphisms o...

Full description

Saved in:
Bibliographic Details
Published in:Cell transplantation 2023-01, Vol.32, p.9636897231151576-9636897231151576
Main Authors: Iravani Saadi, Mahdiyar, Jiang, Mingjun, Banakar, Morteza, Mardani Valandani, Fatemeh, Ahmadyan, Maryam, Rostamipour, Hossain Ali, Kheradmand, Nadiya, Noshadi, Nasrin, Karimi, Zahed, Nabi Abdolyousefi, Ehsan, Ramzi, Mani, Haghighinejad, Hourvash, Yaghobi, Ramin, Hosseini, Fakhroddin
Format: Article
Language:English
Subjects:
CTLA-4 Antigen - genetics
CTLA-4 protein
Gene polymorphism
Genetic Predisposition to Disease
Humans
Infections
Meta-analysis
Organ Transplantation
Original
Polymorphism, Single Nucleotide
Transplantation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organ transplantation has been linked to certain gene polymorphisms. The effect of gene polymorphisms–associated organ transplantation gene on infection, on the other hand, is yet unknown. The research studying the link between the CTLA-4 rs5742909, rs733618, rs4553808, rs231775, and polymorphisms of the organ transplantation gene and infection were found in PubMed, Web of Science, Scopus, and Embase, and the published articles from 2012 to 2020 were gathered. For the best estimation of the intended results, a random-effects model was used in this meta-analysis. In this study, 1,567 studies were initially included and 9 eligible studies were eligible for further analyses. A significant correlation between CTLA4+49 [A/G-231775 odds ratio (OR) = 077, 0.59–0.95] and CTLA4 [rs5742909TT OR: 0.09, 0.27–0.45] gene polymorphism with infection in organ transplantation was observed. Also, no significant association was found between other CTLA4 gene polymorphisms with infection in organ transplantation. Further studies involving gene–gene and gene–diet interactions should be conducted to investigate this association with infection.
ISSN:0963-6897
1555-3892
DOI:10.1177/09636897231151576