Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose

[Display omitted] •Long-term drinking of theabrownin (TB) has an anti-aging effect.•TB improves the learning impairment and liver oxidative stress of aging mice.•TB plays an anti-aging role by regulating intestinal microorganisms.•TB is an active component of tea with excellent application potential...

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Published in:Journal of functional foods 2022-02, Vol.89, p.104941, Article 104941
Main Authors: Lei, Shuwen, Zhang, Zhifang, Xie, Guihua, Zhao, Chunyan, Miao, Yue, Chen, Dehong, Zhang, Guangren, Liu, Hao, Peng, Chunxiu, Hou, Yan, Gong, Jiashun
Format: Article
Language:English
Subjects:
Aging
anti-aging properties
blood glucose
blood serum
fermentation
galactose
Gut microbiota
inflammation
interleukin-2
interleukin-6
intestinal microorganisms
liver
memory
Metabolites
metabolome
metabolomics
oxidation
oxidative stress
polyphenols
small intestine
tea
Theabrownin
weight loss
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Summary:[Display omitted] •Long-term drinking of theabrownin (TB) has an anti-aging effect.•TB improves the learning impairment and liver oxidative stress of aging mice.•TB plays an anti-aging role by regulating intestinal microorganisms.•TB is an active component of tea with excellent application potential. Theabrownin (TB) is a complex oxidized polyphenol formed during the microbial fermentation of Pu-erh tea. It offers some health benefits such as weight loss, blood glucose reduction, and oxidation resistance; however, the anti-aging effect and the related mechanism have not yet been explored. In this study, symptoms of aging were induced in mice using D-galactose. Morris water maze test, hematoxylin-eosin staining, 16S rDNA high-throughput sequencing, and UHPLC-QE-MS metabolomics were used to reveal the anti-aging effects and potential mechanism of TB. TB improved the learning and memory ability, the liver oxidative stress (SOD, GSH-Px, and MDA), inflammation (IL-2, IL-6, and TNF-α), and degeneration of the small intestine in the aging mice. Further analysis showed that TB pretreatment increased the relative abundance of Lactobacillus_murinus and Bacteroides_acidifaciens, and regulated 19 metabolites in the serum. In addition, TB treatment increased the relative abundance of Akkermansia_muciniphila, and regulated 12 metabolites. In conclusion, the anti-aging effect of TB is exerted by the targeted regulation of intestinal microorganisms, which could prevent and delay aging.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2022.104941