TRIM5α 136Q, CCR5 Promoter 59029G And CCR264I Alleles Impact The Progression Of HIV In Children And Adolescents

• Published in: Application of clinical genetics 2019, Vol.12, p.203-211
• Main Authors: Dambaya, Béatrice, Nkenfou, Céline Nguefeu, Mekue, Linda, Této, Georges, Ngoufack, Nicole, Ambada, Georgia, Flobert, Njiokou, Colizzi, Vittorio, Alexis, Ndjolo
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Adolescents; AIDS; aids related genes; Alleles; Antiretroviral drugs; CCR2 protein; CCR5 protein; CD4 antigen; Chemokines; Children; Deoxyribonucleic acid; DNA; Gene amplification; Gene polymorphism; Genetic analysis; HIV; hiv progression; Human immunodeficiency virus; infected children; Infections; Ligands; Monocyte chemoattractant protein 1; Mutation; Original Research; Polymorphism; Population studies; Tuberculosis
• ISSN: 1178-704X; 1178-704X
• DOI: 10.2147/TACG.S205335

Children show various degrees of vulnerability regarding HIV infection and disease progression. This disparity presents challenges for the follow-up of infected children. Here we investigated reasons behind this variability focusing on some host-related HIV genes. We screened 570 Cameroonian children and adolescents, aged 1 to 19 years old. Among them, 137 were followed over 4 years, from 2010 to 2015. Upon signing a proxy consent, children and adolescents were classified according to their age, CD4 count, viral load and clinical symptoms as long-term non-progressors (LTNP), slow progressors (SP) and rapid progressors (RP). Their blood was collected every 6 months and used for biological and host genetic polymorphism analyses. Five genes were genotyped: promoter and . Exposed non-infected (HEU) and unexposed HIV negative children (HNEU) were recruited as control groups. Among the 5 genes studied, the protective allele of Trim5α (R136Q) was present in all LTNP and in 72.34% and 2.56% of SP and RP, respectively (p