The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

Laboratory model organisms have provided a window into how the immune system functions. An increasing body of evidence, however, suggests that the immune responses of naive laboratory animals may differ substantially to those of their wild counterparts. Past exposure, environmental challenges and ph...

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Bibliographic Details
Published in:PLoS pathogens 2024-04, Vol.20 (4), p.e1012119
Main Authors: Mair, Iris, Fenn, Jonathan, Wolfenden, Andrew, Lowe, Ann E., Bennett, Alex, Muir, Andrew, Thompson, Jacob, Dieumerci, Olive, Logunova, Larisa, Shultz, Susanne, Bradley, Janette E., Else, Kathryn J.
Format: Article
Language:English
Subjects:
Adaptive immunity
Adults
Age
Analysis
Animals
Antigens
Biomedical research
CD4 antigen
Comparative analysis
Cytokines
Disease transmission
Environmental impact
Helper cells
Immune response
Immune system
Immunological memory
Immunology
Infections
Laboratories
Laboratory animals
Livestock
Lymphocytes
Lymphocytes T
Memory cells
Mice
Parasites
Phenotypes
Physiological aspects
Prevention
Regression analysis
T cells
Testing
Trichuris
Wildlife
Worms
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