Effect of Carrageenans on Vegetable Jelly in Humans with Hypercholesterolemia

Changes in lipid profile constitute the main risk factor for cardiovascular diseases. Algae extracted carrageenans are long-chain polysaccharides and their ability to form gels provides for the formation of vegetable jelly. The objective was to evaluate the bioactive potential of carrageenan (E407)...

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Bibliographic Details
Published in:Marine drugs 2019-12, Vol.18 (1), p.19
Main Authors: Valado, Ana, Pereira, Maria, Caseiro, Armando, Figueiredo, João P, Loureiro, Helena, Almeida, Carla, Cotas, João, Pereira, Leonel
Format: Article
Language:English
Subjects:
Algae
Biological activity
Cardiovascular diseases
Carrageenan
Carrageenan - chemistry
Carrageenan - pharmacology
Carrageenan - therapeutic use
Carrageenans
Cholesterol
Collections
Density
Diet
Female
Food products
Gels
Gender
hdl-c
Health risks
High density lipoprotein
Humans
Hypercholesterolemia
Hypercholesterolemia - drug therapy
Ingestion
ldl-c
Lipid Metabolism - drug effects
Lipids
Lipoproteins
Low density lipoprotein
Male
Middle Aged
Pharmaceuticals
Polysaccharides
Risk analysis
Risk factors
Saccharides
Serum
Spectrophotometers
Spectrum analysis
Statistical analysis
Statistical methods
tc reduction
Triglycerides
Vegetables
Vegetables - chemistry
Young Adult
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Summary:Changes in lipid profile constitute the main risk factor for cardiovascular diseases. Algae extracted carrageenans are long-chain polysaccharides and their ability to form gels provides for the formation of vegetable jelly. The objective was to evaluate the bioactive potential of carrageenan (E407) in the lipid profile, after ingestion of jelly. A total of 30 volunteers of both sexes, aged 20-64 years and with total cholesterol (TC) values ≥200 mg/dL, who ingested 100 mL/day of jelly for 60 days, were studied. All had two venous blood collections: before starting the jelly intake and after 60 days. At both times, TC, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG), were evaluated using commercial kits and spectrophotometer. The statistics were performed using the SPSS 25.0 software and p < 0.05 were considered statistically significant. Serum values after 60 days of jelly intake revealed a statistically significant decrease in TC levels (5.3%; p = 0.001) and LDL-C concentration (5.4%; p = 0.048) in females. The daily intake of vegetable jelly for 60 days showed a reduction in serum TC and LDL-C levels in women, allowing us to conclude that carrageenan has bioactive potential in reducing TC concentration.
ISSN:1660-3397
1660-3397
DOI:10.3390/md18010019