The relationship between hydration status, male sexual dysfunction and depression in hemodialysis patients

Disturbances in sexual function are common among dialysis patients. Normal erections require a complex balance of physiological, psychological, emotional, hormonal, neurological and vascular factors. This study examined a possible association of overhydration (OH) with male sexual dysfunction and de...

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Bibliographic Details
Published in:Therapeutics and clinical risk management 2018-01, Vol.14, p.523-529
Main Authors: Hassan, Kamal, Elimeleh, Yotam, Shehadeh, Mona, Fadi, Hassan, Rubinchik, Irina
Format: Article
Language:English
Subjects:
Beck Depression Inventory score
Blood pressure
Body mass index
Dehydroepiandrosterone
depression
Diabetes
Erectile dysfunction
Estradiol
Estrogens
Family medical history
Hemodialysis
Hormones
Hydration
Hypertension
Impotence
International Index of Erectile Function score
Kidney diseases
Mental depression
Original Research
overhydration
Peritoneal dialysis
Phenols (Class of compounds)
Physiological aspects
Psychological aspects
Quality of life
Sex hormones
Sexual disorders
Spectroscopy
Testosterone
Urology
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Summary:Disturbances in sexual function are common among dialysis patients. Normal erections require a complex balance of physiological, psychological, emotional, hormonal, neurological and vascular factors. This study examined a possible association of overhydration (OH) with male sexual dysfunction and depression in hemodialysis (HD) patients. This cross-sectional study assessed hydration status by whole-body bioimpedance spectroscopy in patients on maintenance HD for more than 12 months. Patients were categorized according to OH to extracellular water (ECW) ratio: OH/ECW ratio >0.15 and OH/ECW ratio ≤0.15. Sexual function was assessed using the International Index of Erectile Function (IIEF) score. Psychological status was evaluated using the Beck Depression Inventory (BDI) score. Serum sex hormones were determined. Of 39 stable participants on HD, 53.8% were overhydrated (OH/ECW ratio >0.15) and 46.2% not overhydrated (OH/ECW ratio ≤0.15). Of participants with OH/ECW ratio >0.15, 85.7% had mild to severe ED, and 71.4% had abnormal BDI scores, ranging from mild mood disturbance to severe depression. Compared to patients with OH/ECW ratio ≤0.15, BDI scores, serum estradiol and plasma hsCRP were higher (18.48±8.34 vs 10.61±5.46, 0.15, while their IIEF score, serum total testosterone and dehydroepiandrosterone (DHEA) were lower (12.81±7.31 vs 41.44±23.79,
ISSN:1176-6336
1178-203X
1178-203X
DOI:10.2147/TCRM.S147723