Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats

Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins. Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats. Eighteen...

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Published in:PeerJ (San Francisco, CA) CA), 2023-12, Vol.11, p.e16576-e16576, Article e16576
Main Authors: El-Shehry, Mona S E F, Amrymi, Rafa A, Atia, Tarek, Lotfy, Bassant M M, Ahmed, Salma H A, Qutb, Sarah A, Ali, Sara B, Mohamed, Ayman S, Mousa, Mohamed R, Damanhory, Ahmed A, Metawee, Mostafa E, Sakr, Hader I
Format: Article
Language:English
Subjects:
Acids
Alkaline phosphatase
Anemia
Antioxidants
Aspartate
Bilirubin
Biochemistry
Chromatography
Creatinine
Echinochrome
Erythrocytes
Ethylenediaminetetraacetic acid
Glutathione
Glutathione transferase
Health aspects
Hemoglobin
Hemolytic Anemia
Histology
Hydrazine
Inflammation
Kidneys
Laboratory animals
Lipid peroxidation
Liver
Metabolic Sciences
Molecular Biology
Nitric oxide
Oxidative stress
Phenylhydrazine
Phosphatases
Pigments
Urea
Uric acid
γ-Glutamyltransferase
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Summary:Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins. Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats. Eighteen rats were divided into three groups ( = 6): the control group, the phenylhydrazine-induced HA group and the Ech group, injected intraperitoneally with PHZ and supplemented with oral Ech daily for 6 days. Ech resulted in a considerable increase in RBCs, WBCs, and platelets counts, hemoglobin, reduced glutathione, catalase, and glutathione-S-transferase levels, and a significant decrease in aspartate & alanine aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, creatinine, urea, urate, malondialdehyde & nitric oxide levels in anemic rats. Histopathological examination of liver and kidney tissue samples showed marked improvement. Ech ameliorated phenylhydrazine-induced HA with a hepatorenal protective effect owing to its anti-inflammatory and antioxidant properties.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.16576