Closed cranial window rodent model for investigating hemodynamic response to elevated intracranial pressure

Background Elevated intracranial pressure (ICP) occurs in several physiological and pathological conditions, yet long‐term sequellae are not common, which implies that blood flow is preserved above ischemic thresholds. Methods This pilot study sought to confirm this hypothesis using a closed cranial...

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Bibliographic Details
Published in:Animal models and experimental medicine 2021-12, Vol.4 (4), p.391-397
Main Authors: Oberdier, Matt T., Antaki, James F., Kharlamov, Alexander, Jones, Stephen C.
Format: Article
Language:English
Subjects:
Animals
Blood flow
Carbon dioxide
cerebrovascular circulation
Cerebrovascular Circulation - physiology
craniotomy
Doppler effect
Grinding tools
hemodynamics
Hemodynamics - physiology
Hemostasis
hydrocephalus
Intracranial Hypertension
Intracranial pressure
Intracranial Pressure - physiology
Ischemia
Laboratory animals
Lasers
Neurosurgery
Open source software
Original
Perfusion
Pilot Projects
Prospective Studies
Protein biosynthesis
Protein turnover
Rats
Regular
Rodentia
Sinuses
Skull
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Summary:Background Elevated intracranial pressure (ICP) occurs in several physiological and pathological conditions, yet long‐term sequellae are not common, which implies that blood flow is preserved above ischemic thresholds. Methods This pilot study sought to confirm this hypothesis using a closed cranial window model in a rat in which ICP was elevated to 120 mmHg for 12 min, and superficial cortical perfusion was measured by laser Doppler flowmetry and laser speckle flowmetry. Results Following a transient increase, cortical blood flow decreased to between 25% and 75% of baseline. These levels correspond to disrupted metabolism and decreased protein synthesis but did not exceed thresholds for electrical signaling or membrane integrity. This may partially explain how some episodes of elevated ICP remain benign. Conclusion The closed cranial window model provides a platform for prospective study of physiologic responses to artificially elevated ICP during neurosurgery to promote hemostasis.
ISSN:2576-2095
2096-5451
2576-2095
DOI:10.1002/ame2.12187