Sulfated Polysaccharides from Seaweed Strandings as Renewable Source for Potential Antivirals against Herpes simplex Virus 1

virus 1 (HSV-1) remains a prominent health concern widespread all over the world. The increasing genital infections by HSV-1 that might facilitate acquisition and transmission of HIV-1, the cumulative evidence that HSV-1 promotes neurodegenerative disorders, and the emergence of drug resistance sign...

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Published in:Marine drugs 2022-02, Vol.20 (2), p.116
Main Authors: Pliego-Cortés, Hugo, Hardouin, Kévin, Bedoux, Gilles, Marty, Christel, Cérantola, Stéphane, Freile-Pelegrín, Yolanda, Robledo, Daniel, Bourgougnon, Nathalie
Format: Article
Language:English
Subjects:
Algae
Alzheimer's disease
Animals
Antiviral activity
Antiviral agents
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Chemical composition
Chlorocebus aethiops
Cytotoxicity
Disease transmission
Drug resistance
Enzymes
France
Halymenia floresii
Herpes simplex
Herpes viruses
Herpesvirus 1, Human - drug effects
HIV
Human immunodeficiency virus
Infections
Ion exchange
Life Sciences
Mexico
Molecular Weight
Natural products
Neurodegenerative diseases
NMR
Nuclear magnetic resonance
Polysaccharides
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
red seaweed
Saccharides
Sargassum muticum
Seaweed - chemistry
Seaweeds
Solieria chordalis
Stranding
Sulfates
Toxicity
Ulva sp
Vero Cells
Viral infections
Viruses
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cited_by cdi_FETCH-LOGICAL-c506t-78f6e3595b11ddc7d2b6eaf7aefec2ae97815ea8262e8ccec338a05da2b9a4433
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container_title Marine drugs
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creator Pliego-Cortés, Hugo
Hardouin, Kévin
Bedoux, Gilles
Marty, Christel
Cérantola, Stéphane
Freile-Pelegrín, Yolanda
Robledo, Daniel
Bourgougnon, Nathalie
description virus 1 (HSV-1) remains a prominent health concern widespread all over the world. The increasing genital infections by HSV-1 that might facilitate acquisition and transmission of HIV-1, the cumulative evidence that HSV-1 promotes neurodegenerative disorders, and the emergence of drug resistance signify the need for new antiviral agents. In this study, the in vitro anti-herpetic activity of sulfated polysaccharides (SPs) extracted by enzyme or hot water from seaweeds collected in France and Mexico from stranding events, were evaluated. The anti-herpetic activity evaluation of the semi-refined-polysaccharides (sr-SPs) and different ion exchange purified fractions showed a wide range of antiviral activity. Among them, the sr-SPs from the Rhodophyta showed stronger activity EC 0.68 μg/mL with SI 1470, without cytotoxicity. Further, the antiviral activity of the sr-SPs evaluated at different treatment schemes showed a high EC of 0.38 μg/mL during the viral adsorption assays when the polysaccharide and the virus were added simultaneously, whilst the protection on Vero cell during the post-infection assay was effective up to 1 h. The chemical composition, FTIR and H NMR spectroscopic, and molecular weights of the sr-SPs from were determined and discussed based on the anti-herpetic activity. The potential utilization of seaweed stranding as a source of antiviral compounds is addressed.
doi_str_mv 10.3390/md20020116
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ispartof Marine drugs, 2022-02, Vol.20 (2), p.116
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source Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central
subjects Algae
Alzheimer's disease
Animals
Antiviral activity
Antiviral agents
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Chemical composition
Chlorocebus aethiops
Cytotoxicity
Disease transmission
Drug resistance
Enzymes
France
Halymenia floresii
Herpes simplex
Herpes viruses
Herpesvirus 1, Human - drug effects
HIV
Human immunodeficiency virus
Infections
Ion exchange
Life Sciences
Mexico
Molecular Weight
Natural products
Neurodegenerative diseases
NMR
Nuclear magnetic resonance
Polysaccharides
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
red seaweed
Saccharides
Sargassum muticum
Seaweed - chemistry
Seaweeds
Solieria chordalis
Stranding
Sulfates
Toxicity
Ulva sp
Vero Cells
Viral infections
Viruses
title Sulfated Polysaccharides from Seaweed Strandings as Renewable Source for Potential Antivirals against Herpes simplex Virus 1
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