Long term sepsis readmission, mortality and cause of death following Gram negative bloodstream infection: a propensity matched observational linkage study

•GN-BSI patients have poor long-term mortality in comparison to a matched cohort•The underlying cause of death was due to infection only within the first 90 days•Sepsis was the contributory cause of death for one year after GN-BSI Understand the long-term mortality, risk of readmission for sepsis an...

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Bibliographic Details
Published in:International journal of infectious diseases 2022-01, Vol.114, p.34-44
Main Authors: McNamara, John F., Harris, Patrick N.A., Chatfield, Mark D., Paterson, David L.
Format: Article
Language:English
Subjects:
Australia
Bacteremia - epidemiology
bloodstream infection
Cause of Death
Cohort Studies
gram negative
Humans
mortality
Patient Readmission
Retrospective Studies
Risk Factors
Sepsis
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Summary:•GN-BSI patients have poor long-term mortality in comparison to a matched cohort•The underlying cause of death was due to infection only within the first 90 days•Sepsis was the contributory cause of death for one year after GN-BSI Understand the long-term mortality, risk of readmission for sepsis and cause of death following a gram-negative bloodstream infection (GN-BSI). This was a propensity-matched study using data linkage of Queensland hospital data, Australia. GN-BSIs were collected from 2005 to 2010 and matched 1:1 to hospital admissions without BSI for age, gender, year of culture collection, frequency of admissions in the prior year and Charlson-Deyo Comorbidity score and each comorbidity within the Charlson-Deyo score. Readmissions for sepsis, mortality and causes of death were evaluated. Cases of GN-BSI were propensity-matched 1:1 to culture-negative hospital admissions (n = 14016). Readmissions for sepsis were higher in the GN-BSI cohort from 91 to 365 days (P 
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2021.10.047