Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

BackgroundThe optimal time to commence anticoagulation in patients with atrial fibrillation (AF) after ischaemic stroke or transient ischaemic attack (TIA) is unclear, with guidelines differing in recommendations. A limitation of previous studies is the focus on clinically overt stroke, rather than...

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Published in:Stroke and vascular neurology 2024-02, Vol.9 (1), p.30-37
Main Authors: Sharobeam, Angelos, Lin, Longting, Lam, Christina, Garcia-Esperon, Carlos, Gawarikar, Yash, Patel, Ronak, Lee-Archer, Matthew, Wong, Andrew, Roizman, Michael, Gilligan, Amanda, Lee, Andrew, Tan, Kee Meng, Day, Susan, Levi, Christopher, Davis, Stephen M, Parsons, Mark, Yan, Bernard
Format: Article
Language:English
Subjects:
Anticoagulants
Asymptomatic
Atrial Fibrillation
Cardiac arrhythmia
Hemorrhage
Hypotheses
Ischemia
Ischemic Attack, Transient
Magnetic Resonance Imaging
Medical imaging
Neuroimaging
Original Research
Regression analysis
Stroke
Transient ischemic attack
Volumetric analysis
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Summary:BackgroundThe optimal time to commence anticoagulation in patients with atrial fibrillation (AF) after ischaemic stroke or transient ischaemic attack (TIA) is unclear, with guidelines differing in recommendations. A limitation of previous studies is the focus on clinically overt stroke, rather than radiologically obvious diffusion-weighted imaging ischaemic lesions. We aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1 month in patients commenced on early (5 mL, regardless of anticoagulation timing.ConclusionCommencing anticoagulation
ISSN:2059-8688
2059-8696
DOI:10.1136/svn-2023-002357