Prognostic Role of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in the Survival of Patients with Esophageal Cancer

• Published in: Basic and clinical cancer research 2021-12, Vol.12 (4)
• Main Authors: Tajik, Maryam, Shirkhoda, Mohammad, Hadji, Maryam, Seyyed- salehi, Monireh Sadat, Saeidi, Elnaz, Zendehdel, Kazem
• Format: Article
• Language: English
• Subjects: esophageal cancer; lymphocytes; neutrophils; platelets; surgery; survival
• ISSN: 2228-6527; 2228-5466
• DOI: 10.18502/bccr.v12i4.7981

Background: Different factors can affect the future of a person with cancer. The patient’s systemic inflammatory response is an important factor. Several inflammatory markers have been evaluated for measuring the patient’s response to cancer. We evaluated neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as prognostic factors for survival in patients with pathologically proven esophageal cancer. Methods: In this retrospective cohort study, patients with pathologically approved esophageal cancer, who underwent surgical treatment in the cancer institute of Iran, were included. Demographic, pathological, and laboratory data of patients were obtained from the archive of medical records. Results: In this study, 135 patients with esophageal cancer with a mean age of 60 were studied. The median time of the follow-up period was 21 months. Mean NLR and PLR were 7.05 and 898, respectively. Patients’ survival had a significant relationship with their age, gender, tumor differentiation, receiving chemotherapy, absolute neutrophil count, total bilirubin, direct bilirubin, and NLR. Conclusion: According to the results, in a multivariable investigation, it was demonstrated that a high NLR has a direct effect on patients’ poor survival.