Cardiovascular autonomic neuropathy and the risk of diabetic kidney disease

• Published in: Frontiers in endocrinology (Lausanne) 2024-09, Vol.15, p.1462610
• Main Authors: Cho, Injeong, Lim, Seohyun, Kwon, Minjae, Chung, Seung Min, Moon, Jun Sung, Yoon, Ji Sung, Won, Kyu Chang
• Format: Article
• Language: English
• Subjects: Adult; Aged; autonomic nervous system diseases; Autonomic Nervous System Diseases - complications; Autonomic Nervous System Diseases - etiology; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; diabetes complications; diabetes mellitus; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 2 - complications; diabetic nephropathies; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - etiology; diabetic neuropathies; Diabetic Neuropathies - epidemiology; Diabetic Neuropathies - etiology; Endocrinology; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Republic of Korea - epidemiology; Risk Factors
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1462610

Cardiovascular autonomic neuropathy (CAN) is known to affect patients with diabetes mellitus (DM) and cause adverse renal outcomes. We aimed to analyze the association between CAN and diabetic kidney disease (DKD). We enrolled 254 DM patients (mean age, 56.7 ± 15.2 years; male: female ratio, 1.17:1) with 19 (7.5%) type 1 DM patients and 235 (92.5%) type 2 DM patients. All patients had undergone cardiovascular autonomic function tests between January 2019 and December 2021 in a tertiary hospital in Korea. Cardiovascular autonomic neuropathy was categorized as normal, early, or definite after measuring three heart rate variability parameters. Diabetic kidney disease refers to a persistently elevated urinary albumin-creatinine ratio (uACR ≥30 mg/g) or reduced estimated glomerular filtration rate (eGFR