Reproductive-Toxicity-Related Endpoints in C. elegans Are Consistent with Reduced Concern for Dimethylarsinic Acid Exposure Relative to Inorganic Arsenic

Exposures to arsenic and mercury are known to pose significant threats to human health; however, the effects specific to organic vs. inorganic forms are not fully understood. ( ) transparent cuticle, along with the conservation of key genetic pathways regulating developmental and reproductive toxico...

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Bibliographic Details
Published in:Journal of developmental biology 2023-04, Vol.11 (2), p.18
Main Authors: Camacho, Jessica A, Welch, Bonnie, Sprando, Robert L, Hunt, Piper R
Format: Article
Language:English
Subjects:
Animal models
Apoptosis
Arsenic
Arsenite
C. elegans
Cell differentiation
Dimethylarsinic acid
Dimethylmercury
E coli
Eggs
Endangered & extinct species
Histones
inorganic
Meiosis
Mercuric chloride
mercury
Mercury compounds
organic
reproductive-toxicity-related
Sodium arsenite
Toxicity
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Summary:Exposures to arsenic and mercury are known to pose significant threats to human health; however, the effects specific to organic vs. inorganic forms are not fully understood. ( ) transparent cuticle, along with the conservation of key genetic pathways regulating developmental and reproductive toxicology (DART)-related processes such as germ stem cell renewal and differentiation, meiosis, and embryonic tissue differentiation and growth, support this model's potential to address the need for quicker and more dependable testing methods for DART hazard identification. Organic and inorganic forms of mercury and arsenic had different effects on reproductive-related endpoints in , with methylmercury (meHgCl) having effects at lower concentrations than mercury chloride (HgCl ), and sodium arsenite (NaAsO ) having effects at lower concentrations than dimethylarsinic acid (DMA). Progeny to adult ratio changes and germline apoptosis were seen at concentrations that also affected gravid adult gross morphology. For both forms of arsenic tested, germline histone regulation was altered at concentrations below those that affected progeny/adult ratios, while concentrations for these two endpoints were similar for the mercury compounds. These findings are consistent with corresponding mammalian data, where available, suggesting that small animal model test systems may help to fill critical data gaps by contributing to weight of evidence assessments.
ISSN:2221-3759
2221-3759
DOI:10.3390/jdb11020018