Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson’s Disease

Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson’s disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Se...

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Bibliographic Details
Published in:Parkinson's disease 2019-01, Vol.2019 (2019), p.1-8
Main Authors: Kenna, Jade, Walters, Sue, Hince, Dana, Anderton, R. S., McGregor, Sarah, Horne, Malcolm, Mastaglia, Frank L., Ghosh, Soumya, Byrnes, Michelle, Riley, Maddeson, Jefferson, Alexa, Bakeberg, Megan C., Stell, Rick
Format: Article
Language:English
Subjects:
Ethylenediaminetetraacetic acid
Folic acid
Homocysteine
Medical research
Medicine, Experimental
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Summary:Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson’s disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson’s disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to determine whether serum markers are associated with various symptom outcome measures. Results. People with Parkinson’s disease displayed significantly elevated homocysteine levels (p
ISSN:2090-8083
2042-0080
DOI:10.1155/2019/3124295