Exploring the Association between Citrus Nutraceutical Eriocitrin and Metformin for Improving Pre-Diabetes in a Dynamic Microbiome Model

Pre-diabetes is recognized as an altered metabolic state, which precedes type 2 diabetes, and it is associated with great dysfunction of the intestinal microbiota, known as dysbiosis. Natural compounds, capable of reducing blood glucose without side effects and with a beneficial effect on the microb...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-04, Vol.16 (5), p.650
Main Authors: Cesar, Thais, Salgaço, Mateus Kawata, Mesa, Victoria, Sartoratto, Adilson, Sivieri, Katia
Format: Article
Language:English
Subjects:
Care and treatment
Citrus fruits
Colon
Diabetes
Dosage and administration
Drug therapy
Flavonoids
Functional foods
Functional foods & nutraceuticals
Glucose
Health aspects
Insulin resistance
lemon flavonoids
Metabolism
Metabolites
Metformin
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Peptides
Permeability
Physiological aspects
Polyphenols
prebiotic
Prediabetic state
short-chain fatty acids
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Summary:Pre-diabetes is recognized as an altered metabolic state, which precedes type 2 diabetes, and it is associated with great dysfunction of the intestinal microbiota, known as dysbiosis. Natural compounds, capable of reducing blood glucose without side effects and with a beneficial effect on the microbiota, have been studied as substitutes or adjuvants to conventional hypoglycemic agents, such as metformin. In this work, the effect of the nutraceutical Eriomin , a mixture of citrus flavonoids (eriocitrin, hesperidin, naringin, and didymin), which reduces glycemia and increases glucagon-like peptide-1 (GLP-1) in pre-diabetic patients, was tested in the Simulator of Human Intestinal Microbial Ecosystem (SHIME ), inoculated with pre-diabetic microbiota. After treatment with Eriomin plus metformin, a significant increase in acetate and butyrate production was observed. Furthermore, sequencing of the 16S rRNA gene of the microorganisms showed that Eriomin plus metformin stimulated the growth of and genera. are the largest fraction of the intestinal microbiota and are potential colonizers of the colon, with some species producing acetic and propionic fatty acids. In addition, species are associated with better host glycemic metabolism. In conclusion, Eriomin associated with metformin improved the composition and metabolism of the intestinal microbiota, suggesting a potential use in pre-diabetes therapy.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16050650