Classification of breast cancer histology images using MSMV-PFENet

• Published in: Scientific reports 2022-10, Vol.12 (1), p.17447-10, Article 17447
• Main Authors: Liu, Linxian, Feng, Wenxiang, Chen, Cheng, Liu, Manhua, Qu, Yuan, Yang, Jiamiao
• Format: Article
• Language: English
• Subjects: 631/114/1305; 631/114/1386; 631/114/1564; 631/67/1347; 639/705/117; Breast - pathology; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Carcinogenesis; Cell Nucleus - pathology; Classification; Datasets; Deep learning; Diagnosis; Female; Histology; Humanities and Social Sciences; Humans; Long short-term memory; Medical diagnosis; Methods; multidisciplinary; Neural networks; Neural Networks, Computer; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-22358-y

Deep learning has been used extensively in histopathological image classification, but people in this field are still exploring new neural network architectures for more effective and efficient cancer diagnosis. Here, we propose multi-scale, multi-view progressive feature encoding network (MSMV-PFENet) for effective classification. With respect to the density of cell nuclei, we selected the regions potentially related to carcinogenesis at multiple scales from each view. The progressive feature encoding network then extracted the global and local features from these regions. A bidirectional long short-term memory analyzed the encoding vectors to get a category score, and finally the majority voting method integrated different views to classify the histopathological images. We tested our method on the breast cancer histology dataset from the ICIAR 2018 grand challenge. The proposed MSMV-PFENet achieved 93.0 % and 94.8 % accuracies at the patch and image levels, respectively. This method can potentially benefit the clinical cancer diagnosis.