Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy

Reliable early assessment of breast cancer response to neoadjuvant therapy (NAT) would provide considerable benefit to patient care and ongoing research efforts, and demand for accurate and noninvasive early-response biomarkers is likely to increase. Response assessment techniques derived from quant...

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Bibliographic Details
Published in:Breast cancer targets and therapy 2012-01, Vol.2012 (4), p.139-154
Main Authors: Abramson, Richard G, Arlinghaus, Lori R, Weis, Jared A, Li, Xia, Dula, Adrienne N, Chekmenev, Eduard Y, Smith, Seth A, Miga, Michael I, Abramson, Vandana G, Yankeelov, Thomas E
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Care and treatment
Diagnosis
Magnetic resonance imaging
Methods
neoadjuvant chemotherapy
NMR
Nuclear magnetic resonance
presurgical treatment
Review
treatment response
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Summary:Reliable early assessment of breast cancer response to neoadjuvant therapy (NAT) would provide considerable benefit to patient care and ongoing research efforts, and demand for accurate and noninvasive early-response biomarkers is likely to increase. Response assessment techniques derived from quantitative magnetic resonance imaging (MRI) hold great potential for integration into treatment algorithms and clinical trials. Quantitative MRI techniques already available for assessing breast cancer response to neoadjuvant therapy include lesion size measurement, dynamic contrast-enhanced MRI, diffusion-weighted MRI, and proton magnetic resonance spectroscopy. Emerging yet promising techniques include magnetization transfer MRI, chemical exchange saturation transfer MRI, magnetic resonance elastography, and hyperpolarized MR. Translating and incorporating these techniques into the clinical setting will require close attention to statistical validation methods, standardization and reproducibility of technique, and scanning protocol design.
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S35882