Clinical Outcomes and Virulence Factors of Shiga Toxin-Producing Escherichia coli (STEC) from Southern Alberta, Canada, from 2020 to 2022

Shiga toxin-producing (STEC) can cause severe clinical disease in humans, particularly in young children. Recent advances have led to greater availability of sequencing technologies. We sought to use whole genome sequencing data to identify the presence or absence of known virulence factors in all c...

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Bibliographic Details
Published in:Pathogens (Basel) 2024-09, Vol.13 (10), p.822
Main Authors: Glassman, Heather, Suttorp, Vivien, White, Theron, Ziebell, Kim, Kearney, Ashley, Bessonov, Kyrylo, Li, Vincent, Chui, Linda
Format: Article
Language:English
Subjects:
Age
Causes of
Children
Clinical isolates
Clinical outcomes
Cluster analysis
Communication
Demographic aspects
DNA sequencing
E coli
Escherichia coli
Escherichia coli infections
Gene sequencing
Genetic aspects
Genomes
Hospitalization
Identification and classification
Infections
Inflammatory bowel disease
Kidney diseases
Laboratories
Microbiological research
Nucleotide sequencing
Patient outcomes
Patients
Serotypes
Shiga toxin
Shiga toxin-producing Escherichia coli
Statistical analysis
Surveillance
Toxins
Virulence
Virulence (Microbiology)
Virulence factors
Whole genome sequencing
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Summary:Shiga toxin-producing (STEC) can cause severe clinical disease in humans, particularly in young children. Recent advances have led to greater availability of sequencing technologies. We sought to use whole genome sequencing data to identify the presence or absence of known virulence factors in all clinical isolates submitted to our laboratory from Southern Alberta dated 2020-2022 and correlate these virulence factors with clinical outcomes obtained through chart review. Overall, the majority of HUS and hospitalizations were seen in patients with O157:H7 serotypes, and HUS cases were primarily in young children. The frequency of virulence factors differed between O157:H7 and non-O157 serotypes. Within the O157:H7 cases, certain virulence factors, including , , and , were more frequent in HUS cases. The number of samples was too low to determine statistical significance.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens13100822