Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases

Background. Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA). Subjects and Methods. We measured MDA level...

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Bibliographic Details
Published in:Mediators of Inflammation 2011-01, Vol.2011 (2011), p.416-422
Main Authors: Bartoli, M. L., Novelli, F., Costa, F., Malagrinò, L., Melosini, L., Bacci, E., Cianchetti, S., Dente, F. L., Di Franco, A., Vagaggini, B., Paggiaro, P. L.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers - analysis
Breath Tests
Clinical Study
Development and progression
Exhalation
Female
General aspects
Health aspects
Humans
Lung diseases
Lung Diseases - physiopathology
Male
Malondialdehyde - analysis
Medical sciences
Middle Aged
Organic compounds
Oxidative stress
Oxidative Stress - physiology
Physiological aspects
Respiration
Sputum - chemistry
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Summary:Background. Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA). Subjects and Methods. We measured MDA levels in EBC in a large number of patients (N=194) with respiratory diseases: asthma (N=64), bronchiectasis (BE, N=19), chronic obstructive pulmonary disease (COPD, N=73), idiopathic pulmonary fibrosis (IPF, N=38). Fourteen healthy nonsmoking subjects were included as controls. Results. Excluding IPF subjects, MDA levels were significantly higher in all disease groups than in control group. MDA was significantly higher in COPD than asthmatic and BE subjects. Among asthmatics, corticosteroids-treated subjects had lower MDA levels than untreated subjects. COPD subjects showed an inverse correlation between MDA concentrations and FEV1% (rho:  −0.24, P
ISSN:0962-9351
1466-1861
DOI:10.1155/2011/891752